CRISPR diagnostics based on nucleic acid amplification faces barriers to its commercial
use, such as contamination risks and insufficient sensitivity. Here, we propose a robust …

Genetically encoded tools for the regulation of endogenous molecules (RNA, DNA elements
and protein) are needed to study and control biological processes with minimal interference …

Light is essential for various biochemical processes in all domains of life. In its presence
certain proteins inside a cell are excited, which either stimulates or inhibits subsequent …

Anti-CRISPR (Acr) proteins are encoded by mobile genetic elements to overcome the
CRISPR immunity of prokaryotes, displaying promises as controllable tools for modulating …

Following introduction of CRISPR-Cas9 components into a cell, genome editing occurs
unabated until degradation of its component nucleic acids and proteins by cellular …

The CRISPR/Cas system was first discovered as a defense mechanism in bacteria and is
now used as a tool for precise gene-editing applications. Rapidly evolving, it is increasingly …

Over the last decade, CRISPR has revolutionized drug development due to its potential to
cure genetic diseases that currently do not have any treatment. CRISPR was adapted from …

In the ten years since the discovery of the first anti-CRISPR (Acr) proteins, the number of
validated Acrs has expanded rapidly, as has our understanding of the diverse mechanisms …

CRISPR-Cas systems act as the adaptive immune systems of bacteria and archaea,
targeting and destroying invading foreign mobile genetic elements (MGEs) such as phages …

Background Opsin‐based optogenetics has emerged as a powerful biomedical tool using
light to control protein conformation. Such capacity has been initially demonstrated to control …