An estimated 10–25% of lung cancers worldwide occur in never smokers, ie individuals
having smoked less than 100 cigarettes in their lifetime. Lung cancer in never smokers …

Although most lung cancers are a result of smoking, approximately 25% of lung cancer
cases worldwide are not attributable to tobacco use, accounting for over 300,000 deaths …

An essential resource for all scientists researching cellular responses to DNA damage.•
Introduces important new material reflective of the major changes and developments that …

It is estimated that approximately 25% of all lung cancer cases are observed in never-
smokers and its incidence is expected to increase due to smoking prevention programs …

Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and
are suggested to be related to cancer risk. However, epidemiologic findings have been …

Lung cancer is the major cancer killer worldwide, and 5-yr survival is extremely poor (≤
15%), accentuating the need for more effective therapeutic strategies. Significant advances …

The frequency of cells with structural chromosomal aberrations (CAs) in peripheral blood
lymphocytes is the first genotoxicity biomarker that has shown an association with cancer …

A major barrier to understanding the role of polymorphic DNA repair genes for
environmental cancer is that the functions of variant genotypes are largely unknown. Using …

Lung cancer is the leading cause of cancer mortality worldwide. There have been only slight
improvements in early diagnosis and survival, reflecting limited advances in screening and …

Several potential functional polymorphisms (Arg194Trp, Arg280His, Arg399Gln) in the DNA
base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been …