Precision cancer medicine is a multidisciplinary team effort that requires involvement and
commitment of many stakeholders including the society at large. Building on the success of …

DNA-targeted drugs constitute a specialized category of pharmaceuticals developed for
cancer treatment, directly influencing various cellular processes involving DNA. These drugs …

Background Early-phase clinical trials (EPCT) represent an important part of innovations in
medical oncology and a valuable therapeutic option for patients with metastatic cancers …

Background and purpose In Norway, comprehensive molecular tumour profiling is
implemented as part of the public healthcare system. A substantial number of tumours …

Background In the two European Union (EU)-funded projects, PCM4EU (Personalized
Cancer Medicine for all EU citizens) and PRIME-ROSE (Precision Cancer Medicine …

Background In 2016, genomic profiling was implemented for patients with grade 4 primary
brain tumors at Rigshospitalet, Denmark. The aim of this study was to discover actionable …

Aim Our goal was to describe a precision medicine program in a regional academic hospital,
characterize features of included patients and present early data on clinical impact …

Recent developments in molecular genetic testing methods (eg next-generation sequencing
[NGS]-panels) largely accelerated the process of finding the most appropriate targeted …

Purpose Comprehensive genomic profiling is becoming increasingly important in the
management of patients with metastatic breast cancer (mBC). Real-world clinical outcomes …

Background and purpose The Precision Oncology Platform (POP) trial represents the effort
of the Portuguese Oncology Institute of Porto (IPO Porto) for joining other leading European …