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[HTML][HTML] CRISPR/Cas-based human T cell engineering: basic research and clinical application
Engineering human T cells for the treatment of cancer, viral infections and autoimmunity has
been a long-standing dream of many immunologists and hematologists. Although primary …
been a long-standing dream of many immunologists and hematologists. Although primary …
Non-viral TRAC-knocked-in CD19KICAR-T and gp350KICAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and …
T Braun, A Pruene, M Darguzyte, AF Vom Stein… - Frontiers in …, 2023 - frontiersin.org
Introduction The ubiquitous Epstein–Barr virus (EBV) is an oncogenic herpes virus
associated with several human malignancies. EBV is an immune-evasive pathogen that …
associated with several human malignancies. EBV is an immune-evasive pathogen that …
CRISPR/Cas9 deletion of MIR155HG in human T cells reduces incidence and severity of acute GVHD in a xenogeneic model
L Neidemire-Colley, S Khanal, KM Braunreiter… - Blood …, 2024 - ashpublications.org
Acute graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic
cell transplantation (allo-HCT). Using preclinical mouse models of disease, previous work in …
cell transplantation (allo-HCT). Using preclinical mouse models of disease, previous work in …
Targeted disruption of the BCR-ABL fusion gene by Cas9/dual-sgRNA inhibits proliferation and induces apoptosis in chronic myeloid leukemia cells: Cas9/Dual …
J Zeng, X Liang, L Duan, F Tan, L Chen… - Acta biochimica et …, 2024 - pmc.ncbi.nlm.nih.gov
The BCR-ABL fusion gene, formed by the fusion of the breakpoint cluster region protein
(BCR) and the Abl Oncogene 1, Receptor Tyrosine Kinase (ABL) genes, encodes the BCR …
(BCR) and the Abl Oncogene 1, Receptor Tyrosine Kinase (ABL) genes, encodes the BCR …
CRISPR/Cas9 Genome Editing in the Diamondback Moth: Current Progress, Challenges, and Prospects
M Asad, Y Chang, J Liao, G Yang - International Journal of Molecular …, 2025 - mdpi.com
The development of site-specific genome-editing tools like CRISPR (clustered regularly
interspaced short palindromic repeat) and its associated protein, Cas9, is revolutionizing …
interspaced short palindromic repeat) and its associated protein, Cas9, is revolutionizing …
Whole-Genome Sequencing Reveals Rare Off-Target Mutations in MC1R-Edited Pigs Generated by Using CRISPR-Cas9 and Somatic Cell Nuclear Transfer
Z Li, J Lan, X Shi, T Lu, X Hu, X Liu, Y Chen… - The CRISPR …, 2024 - liebertpub.com
The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system has
been widely used to create animal models for biomedical and agricultural use owing to its …
been widely used to create animal models for biomedical and agricultural use owing to its …
Analytical Methods for In-Process Testing and Product Release
NA Haig, JE Valeich, L DeMaster, C Do… - Handbook of Cell and …, 2023 - taylorfrancis.com
This chapter will focus on the analytical procedures used to support the clinical development
and commercial life cycle management of a CAR T cell product. This hypothetical product …
and commercial life cycle management of a CAR T cell product. This hypothetical product …
Identification, isolation and characterization of T cell receptors for adoptive T cell therapy in tumor and viral infections
KI Wagner - 2022 - mediatum.ub.tum.de
The transfer of T cell immunity for the treatment of viral infections and tumor malignancies by
the adoptive transfer of, respectively, donor-and patient-derived autologous T cells has been …
the adoptive transfer of, respectively, donor-and patient-derived autologous T cells has been …