FTO and obesity: mechanisms of association

X Zhao, Y Yang, BF Sun, YL Zhao, YG Yang - Current diabetes reports, 2014 - Springer
The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for
obesity. However, the exact molecular mechanisms responsible for the effect of FTO on …

Convergence between biological, behavioural and genetic determinants of obesity

S Ghosh, C Bouchard - Nature Reviews Genetics, 2017 - nature.com
Multiple biological, behavioural and genetic determinants or correlates of obesity have been
identified to date. Genome-wide association studies (GWAS) have contributed to the …

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

X Zhao, Y Yang, BF Sun, Y Shi, X Yang, W **ao… - Cell research, 2014 - nature.com
Abstract The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-
methyladenosine (m 6 A) in mRNA processing and adipogenesis remains largely unknown …

[BOK][B] Healthcare data analytics

CK Reddy, CC Aggarwal - 2015 - books.google.com
Supplying a comprehensive overview of healthcare analytics research, Healthcare Data
Analytics provides an understanding of the analytical techniques currently available to solve …

Obesity and eating behavior from the perspective of twin and genetic research

K Silventoinen, H Konttinen - Neuroscience & biobehavioral reviews, 2020 - Elsevier
Obesity has dramatically increased during the last decades and is currently one of the most
serious global health problems. We present a hypothesis that obesity is a neuro-behavioral …

Epigenetic modifications in essential hypertension

IA Wise, FJ Charchar - International journal of molecular sciences, 2016 - mdpi.com
Essential hypertension (EH) is a complex, polygenic condition with no single causative
agent. Despite advances in our understanding of the pathophysiology of EH, hypertension …

Traditional Chinese medicine network pharmacology in cardiovascular precision medicine

L Gao, M Cao, J Li, X Qin, J Fang - Current Pharmaceutical …, 2021 - benthamdirect.com
Cardiovascular disease is a major disease affecting human health, and its pathogenesis is
caused by many factors. Through the use of" omics" technology, precision medicine is …

An analysis of disease-gene relationship from Medline abstracts by DigSee

J Kim, J Kim, H Lee - Scientific reports, 2017 - nature.com
Diseases are developed by abnormal behavior of genes in biological events such as gene
regulation, mutation, phosphorylation, and epigenetics and post-translational modification …

T2DiACoD: a gene atlas of type 2 diabetes mellitus associated complex disorders

J Rani, I Mittal, A Pramanik, N Singh, N Dube… - Scientific reports, 2017 - nature.com
We performed integrative analysis of genes associated with type 2 Diabetes Mellitus (T2DM)
associated complications by automated text mining with manual curation and also gene …

Prioritization of genes associated with type 2 diabetes mellitus for functional studies

WX Tan, X Sim, CM Khoo, AKK Teo - Nature Reviews Endocrinology, 2023 - nature.com
Existing therapies for type 2 diabetes mellitus (T2DM) show limited efficacy or have adverse
effects. Numerous genetic variants associated with T2DM have been identified, but progress …