Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

Cohesin is a chromosome-bound, multisubunit adenosine triphosphatase complex. After
loading onto chromosomes, it generates loops to regulate chromosome functions. It has …

Cohesin catalyses the folding of the genome into loops that are anchored by CTCF. The
molecular mechanism of how cohesin and CTCF structure the 3D genome has remained …

Structural maintenance of chromosomes (SMC) complexes are essential for genome
organization from bacteria to humans, but their mechanisms of action remain poorly …

Chromosomes are organized as chromatin loops that promote segregation, enhancer-
promoter interactions, and other genomic functions. Loops were hypothesized to form by …

Mutations of the cohesin complex in human cancer were first discovered~ 10 years ago.
Since then, researchers worldwide have demonstrated that cohesin is among the most …

3D chromatin organization plays a critical role in regulating gene expression, DNA
replication, recombination, and repair. While initially discovered for its role in sister …

Mammalian Hox gene clusters contain a range of CTCF binding sites. In addition to their
importance in organizing a TAD border, which isolates the most posterior genes from the …

The spatial organization of the genome is critical for fundamental biological processes,
including transcription, genome replication, and segregation. Chromatin is compacted and …