Enzymatic halogenation and dehalogenation reactions: pervasive and mechanistically diverse
Naturally produced halogenated compounds are ubiquitous across all domains of life where
they perform a multitude of biological functions and adopt a diversity of chemical structures …
they perform a multitude of biological functions and adopt a diversity of chemical structures …
An overview on marine sponge-symbiotic bacteria as unexhausted sources for natural product discovery
CM Brinkmann, A Marker, DI Kurtböke - Diversity, 2017 - mdpi.com
Microbial symbiotic communities of marine macro-organisms carry functional metabolic
profiles different to the ones found terrestrially and within surrounding marine environments …
profiles different to the ones found terrestrially and within surrounding marine environments …
Terpene biosynthesis in marine sponge animals
Sea sponges are the largest marine source of small-molecule natural products described to
date. Sponge-derived molecules, such as the chemotherapeutic eribulin, the calcium …
date. Sponge-derived molecules, such as the chemotherapeutic eribulin, the calcium …
Ecological niche-inspired genome mining leads to the discovery of crop-protecting nonribosomal lipopeptides featuring a transient amino acid building block
Investigating the ecological context of microbial predator–prey interactions enables the
identification of microorganisms, which produce multiple secondary metabolites to evade …
identification of microorganisms, which produce multiple secondary metabolites to evade …
Insights into the lifestyle of uncultured bacterial natural product factories associated with marine sponges
G Lackner, EE Peters… - Proceedings of the …, 2017 - National Acad Sciences
The as-yet uncultured filamentous bacteria “Candidatus Entotheonella factor” and
“Candidatus Entotheonella gemina” live associated with the marine sponge Theonella …
“Candidatus Entotheonella gemina” live associated with the marine sponge Theonella …
Bacteria as genetically programmable producers of bioactive natural products
Next to plants, bacteria account for most of the biomass on Earth. They are found
everywhere, although certain species thrive only in specific ecological niches. These …
everywhere, although certain species thrive only in specific ecological niches. These …
Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts
Marine sponges have been a prolific source of unique bioactive compounds that are
presumed to act as a deterrent to predation. Many of these compounds have potential …
presumed to act as a deterrent to predation. Many of these compounds have potential …
Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis
Ribosomally synthesized and post-translationally modified peptides (RiPPs) display a
diverse range of structures and continue to expand as a natural product class. Accordingly …
diverse range of structures and continue to expand as a natural product class. Accordingly …
Enhanced Solubilization of Class B Radical S-Adenosylmethionine Methylases by Improved Cobalamin Uptake in Escherichia coli
ND Lanz, AJ Blaszczyk, EL McCarthy, B Wang… - Biochemistry, 2018 - ACS Publications
The methylation of unactivated carbon and phosphorus centers is a burgeoning area of
biological chemistry, especially given that such reactions constitute key steps in the …
biological chemistry, especially given that such reactions constitute key steps in the …
Characterization of a thaumarchaeal symbiont that drives incomplete nitrification in the tropical sponge Ianthella basta
Marine sponges represent one of the few eukaryotic groups that frequently harbour
symbiotic members of the Thaumarchaeota, which are important chemoautotrophic …
symbiotic members of the Thaumarchaeota, which are important chemoautotrophic …