Due to the obvious advantages of long-acting peptide and protein drugs, strategies to
prolong plasma half life time of such compounds are highly on demand. Short plasma half …

Angioedema is defined as localized and self‐limiting edema of the subcutaneous and
submucosal tissue, due to a temporary increase in vascular permeability caused by the …

Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute
attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to …

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results
in the release of vasoactive kinins (bradykinin-related peptides). This complex system …

Hypertension and heart failure (HF) are common diseases that, despite advances in medical
therapy, continue to be associated with high morbidity and mortality. Therefore, innovative …

Angiotensin-I-converting enzyme (ACE) is a monomeric, membrane-bound, zinc-and
chloride-dependent peptidyl dipeptidase that catalyzes the conversion of the decapeptide …

Current-generation angiotensin-converting enzyme (ACE) inhibitors are widely used for
cardiovascular diseases, including high blood pressure, heart failure, heart attack and …

Abstract Purpose of Review This study aims to examine current knowledge on the
occurrence, pathophysiology, and treatment of angioedema among patients who receive …

Angioedema is an underestimated clinical problem. Many cases are nonallergic reactions,
eg bradykinin‐induced angioedema caused by genetic defects and angiotensin‐converting …

Bradykinin (BK) metabolism and its receptors play a central role in drug-induced
angioedema (AE) without urticaria through increased vascular permeability. Many …