The cancer-immunity cycle provides a framework to understand the series of events that
generate anti-cancer immune responses. It emphasizes the iterative nature of the response …

As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

Hepatocellular carcinoma (HCC) is a major health concern worldwide, with limited
therapeutic options and poor prognosis. In recent years, immunotherapies such as immune …

Cancer patients often receive a combination of antibodies targeting programmed death-
ligand 1 (PD-L1) and cytotoxic T lymphocyte antigen-4 (CTLA4). We conducted a window-of …

Expanding the efficacy of immune checkpoint blockade (ICB) in colorectal cancer (CRC)
presses for a comprehensive understanding of treatment responsiveness. Here, we analyze …

The immune responses during the initiation and invasion stages of human lung
adenocarcinoma (LUAD) development are largely unknown. Here, we generated a single …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors
treated with immune checkpoint blockade, but understanding of the prognostic and …

The tumor microenvironment is a highly complex and dynamic mixture of cell types,
including tumor, immune and endothelial cells (ECs), soluble factors (cytokines …

Tertiary lymphoid structure (TLS) is an ectopic lymphocyte aggregate formed in peripheral
non-lymphoid tissues, including inflamed or cancerous tissue. Tumor-associated TLS serves …