In recent years, the use of integrative, information-driven computational approaches for
modeling the structure of biomolecules has been increasing in popularity. These are now …

Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

Cell-penetrating peptides (CPPs) facilitate translocation across biological membranes and
are of significant biological and medical interest. Several CPPs can permeate into specific …

The oligomerization of protein macromolecules on cell membranes plays a fundamental role
in regulating cellular function. From modulating signal transduction to directing immune …

Membrane proteins are among the most challenging systems to study with experimental
structural biology techniques. The increased number of deposited structures of membrane …

The 99 amino acid C-terminal fragment of Amyloid Precursor Protein APP-C99 (C99) is
cleaved by γ-secretase to form Aβ peptide, which plays a critical role in the etiology of …

Protein–protein interactions (PPIs) are responsible for a number of key physiological
processes in the living cells and underlie the pathomechanism of many diseases …

Proteins play crucial roles in every cellular process by interacting with each other, nucleic
acids, metabolites, and other molecules. The resulting assemblies can be very large and …

Motivation: A wide range of fundamental biological processes are mediated by membrane
proteins. Despite their large number and importance, less than 1% of all 3D protein …

We report the first membrane protein–protein docking benchmark consisting of 37 targets of
diverse functions and folds. The structures were chosen based on a set of parameters such …