The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

One of the most significant conceptual advances in immunology in recent history is the
recognition that signals from the innate immune system are required for induction of …

Improvements in tumor immunotherapies depend on better understanding of the anti-tumor
T cell response. By studying human tumor-draining lymph nodes (TDLNs), we found that …

Local environmental factors influence CD8+ T cell priming in lymph nodes (LNs). Here, we
sought to understand how factors unique to the tumor-draining mediastinal LN (mLN) impact …

Trained immunity refers to a hyperresponsive functional state of the innate immune system,
which is induced by certain stimuli, such as infections or vaccination. Trained immunity plays …

Abstract Thioredoxins (Trxs), glutaredoxins (Grxs), and peroxiredoxins (Prxs) have been
characterized as electron donors, guards of the intracellular redox state, and “antioxidants” …

Melanoma is one of the most immunogenic tumors and its relationship with host immune
system is currently under investigation. Many immunomodulatory mechanisms, favoring …

CD8 T cells require a third signal, along with Ag and costimulation, to make a productive
response and avoid death and/or tolerance induction. Recent studies indicate that IL-12 and …

There is increasing evidence that gut microbiome perturbations, also known as dysbiosis,
can influence colorectal cancer development. To understand the mechanisms by which the …

Chimeric antigen receptor (CAR) T cell therapy has transformed the care of refractory B cell
malignancies and holds tremendous promise for many aggressive tumors. Despite …