In synthetic biology, biological cells and processes are dismantled and reassembled to
make novel systems that do useful things. Designs are encoded by deoxyribonucleic acid …

Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

The COVID-19 pandemic due to the SARS-CoV-2 coronavirus has directly impacted the
public health and economy worldwide. To overcome this problem, countries have adopted …

The stochastic simulation algorithm commonly known as Gillespie's algorithm (originally
derived for modelling well-mixed systems of chemical reactions) is now used ubiquitously in …

Molecular systems orchestrating the biology of the cell typically involve a complex web of
interactions among various components and span a vast range of spatial and temporal …

Wound healing and fibrosis following myocardial infarction (MI) is a dynamic process
involving many cell types, extracellular matrix (ECM), and inflammatory cues. As both …

Managing tourism destinations has become increasingly challenging due to the tourism
ecosystem's complex nature. Tourism destinations can be seen as complex systems …

Multiscale computational modeling aims to connect the complex networks of effects at
different length and/or time scales. For example, these networks often include intracellular …

Abstract Background and objective Cancer Immunoediting (CI) describes the cellular-level
interaction between tumor cells and the Immune System (IS) that takes place in the Tumor …

Modeling and forecasting the spread of COVID-19 remains an open problem for several
reasons. One of these concerns the difficulty to model a complex system at a high resolution …