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Tertiary lymphoid structures in the era of cancer immunotherapy
Tertiary lymphoid structures (TLSs) are ectopic lymphoid organs that develop in non-
lymphoid tissues at sites of chronic inflammation including tumours. Key common …
lymphoid tissues at sites of chronic inflammation including tumours. Key common …
B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity
CM Laumont, BH Nelson - Cancer Cell, 2023 - cell.com
Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …
IL-1 family members in cancer; two sides to every story
The IL-1 family of cytokines currently comprises of seven ligands with pro-inflammatory
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ) as well as two ligands with anti …
High endothelial venules (HEVs) in immunity, inflammation and cancer
L Blanchard, JP Girard - Angiogenesis, 2021 - Springer
High endothelial venules (HEVs) are specialized blood vessels mediating lymphocyte
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …
trafficking to lymph nodes (LNs) and other secondary lymphoid organs. By supporting high …
IL-1 family cytokine regulation of vascular permeability and angiogenesis
E Fahey, SL Doyle - Frontiers in Immunology, 2019 - frontiersin.org
The IL-1 family of cytokines are well-known for their primary role in initiating inflammatory
responses both in response to and acting as danger signals. It has long been established …
responses both in response to and acting as danger signals. It has long been established …
Tertiary lymphoid structures in diseases: immune mechanisms and therapeutic advances
L Zhao, S **, S Wang, Z Zhang, X Wang… - … and Targeted Therapy, 2024 - nature.com
Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …
Tertiary lymphoid structures: diversity in their development, composition, and role
C Gago da Graça, LGM van Baarsen… - The Journal of …, 2021 - journals.aai.org
Lymph node stromal cells coordinate the adaptive immune response in secondary lymphoid
organs, providing both a structural matrix and soluble factors that regulate survival and …
organs, providing both a structural matrix and soluble factors that regulate survival and …
Tertiary lymphoid structures and B lymphocytes in cancer prognosis and response to immunotherapies
Tertiary lymphoid structures (TLS) are ectopic cellular aggregates that resemble secondary
lymphoid organs in their composition and structural organization. In contrast to secondary …
lymphoid organs in their composition and structural organization. In contrast to secondary …
STING agonist-based treatment promotes vascular normalization and tertiary lymphoid structure formation in the therapeutic melanoma microenvironment
M Chelvanambi, RJ Fecek, JL Taylor… - … for immunotherapy of …, 2021 - pmc.ncbi.nlm.nih.gov
Background The degree of immune infiltration in tumors, especially CD8+ T cells, greatly
impacts patient disease course and response to interventional immunotherapy …
impacts patient disease course and response to interventional immunotherapy …
Regulation and function of interleukin‐36 cytokines
Summary The interleukin (IL)‐36 cytokines include 3 agonists, IL‐36α, IL‐36β, and IL‐36γ
that bind to a common receptor composed of IL‐36R and IL‐1 RA cP to stimulate …
that bind to a common receptor composed of IL‐36R and IL‐1 RA cP to stimulate …