Ion mobility-mass spectrometry: time-dispersive instrumentation

JC May, JA McLean - Analytical chemistry, 2015 - ACS Publications
The field of ion mobility-mass spectrometry (IM-MS) has grown with significant momentum in
recent years in both fundamental advances and pioneering applications. A search of the …

Mass spectrometry-based proteomics: existing capabilities and future directions

TE Angel, UK Aryal, SM Hengel, ES Baker… - Chemical Society …, 2012 - pubs.rsc.org
Mass spectrometry (MS)-based proteomics is emerging as a broadly effective means for
identification, characterization, and quantification of proteins that are integral components of …

Conformational ordering of biomolecules in the gas phase: nitrogen collision cross sections measured on a prototype high resolution drift tube ion mobility-mass …

JC May, CR Goodwin, NM Lareau, KL Leaptrot… - Analytical …, 2014 - ACS Publications
Ion mobility-mass spectrometry measurements which describe the gas-phase scaling of
molecular size and mass are of both fundamental and pragmatic utility. Fundamentally, such …

Large-scale prediction of collision cross-section values for metabolites in ion mobility-mass spectrometry

Z Zhou, X Shen, J Tu, ZJ Zhu - Analytical chemistry, 2016 - ACS Publications
The rapid development of metabolomics has significantly advanced health and disease
related research. However, metabolite identification remains a major analytical challenge for …

Deep learning the collisional cross sections of the peptide universe from a million experimental values

F Meier, ND Köhler, AD Brunner, JMH Wanka… - Nature …, 2021 - nature.com
The size and shape of peptide ions in the gas phase are an under-explored dimension for
mass spectrometry-based proteomics. To investigate the nature and utility of the peptide …

Ion mobility collision cross section compendium

JC May, CB Morris, JA McLean - Analytical chemistry, 2017 - ACS Publications
In this Review, we focus on an important aspect of ion mobility (IM) research, namely, the
reporting of quantitative ion mobility measurements in the form of the gas-phase collision …

Recent developments in ion mobility spectrometry

H Borsdorf, T Mayer, M Zarejousheghani… - Applied spectroscopy …, 2011 - Taylor & Francis
The general principles and technical implementations of traditional time-of-flight ion mobility
spectrometers and analyzers with field-dependent mobilities were reviewed in our last …

Update of PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence

HB Rao, F Zhu, GB Yang, ZR Li… - Nucleic acids research, 2011 - academic.oup.com
Sequence-derived structural and physicochemical features have been extensively used for
analyzing and predicting structural, functional, expression and interaction profiles of proteins …

The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomics

C Hinz, S Liggi, JL Griffin - Current opinion in chemical biology, 2018 - Elsevier
Highlights•We review the current advantages of IM-MS spectrometry in lipidomics.•Collision
Cross-Section (CCS) values enhance confidence in lipid identification.•IM separation …

Investigation of the complete suite of the leucine and isoleucine isomers: toward prediction of ion mobility separation capabilities

JN Dodds, JC May, JA McLean - Analytical chemistry, 2017 - ACS Publications
In this study we investigated 11 isomers with the molecular formula C6H13NO2 (m/z 131) to
ascertain the potential of utilizing drift tube ion mobility mass spectrometry to aid in the …