The Rab family of small GTPases regulates intracellular membrane trafficking by
orchestrating the biogenesis, transport, tethering, and fusion of membrane‐bound …

The clinical success of immune checkpoint therapy (ICT) has produced explosive growth in
tumor immunology research because ICT was discovered through basic studies of immune …

There is growing evidence that tumour neoantigens have important roles in generating
spontaneous antitumour immune responses and predicting clinical responses to …

Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …

Dendritic cells (DCs) are a unique class of immune cells that act as a bridge between innate
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …

During the process of cross-presentation, viral or tumor-derived antigens are presented to
CD8+ T cells by Batf3-dependent CD8α+/XCR1+ classical dendritic cells (cDC1s). We …

Conventional dendritic cells (cDCs), cDC1 and cDC2, act both to initiate immunity and
maintain self-tolerance. The tryptophan metabolic enzyme indoleamine 2, 3-dioxygenase 1 …

Abstract Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of
many viral and tumor antigens to CD8+ T cells. cDC1 cells can be identified in mice and …

CD40 signaling in classical type 1 dendritic cells (cDC1s) is required for CD8 T cell-
mediated tumor rejection, but the underlying mechanisms are incompletely understood …

Plasmacytoid dendritic cells (pDCs) have been shown to play an important role during
immune responses, ranging from initial viral control through the production of type I …