This discussion focuses on the cellular dynamics of tRNA transcription, processing, and
turnover. Early tRNA biosynthesis steps are shared among most tRNAs, while later ones are …

INTRODUCTION Naïve T cells activated by cognate antigens and costimulation proliferate
and differentiate to effector T cells. The shift from a resting to a proliferative state entails …

The recognition and translation of mammalian mitochondrial mRNAs are poorly understood.
To gain further insights into these processes in vivo, we characterized mice with a missense …

Abstract RNA polymerase III (Pol III) transcription of tRNA genes is essential for generating
the tRNA adaptor molecules that link genetic sequence and protein translation. By map** …

RNA polymerase (Pol) III synthesizes the tRNAs, the 5S ribosomal RNA and a small number
of untranslated RNAs. In vitro, it also transcribes short interspersed nuclear elements …

The DNA of living cells is highly compacted. Inherent in this spatial constraint is the need for
cells to organize individual genetic loci so as to facilitate orderly retrieval of information …

The structure and function of transfer RNA (tRNA) genes have been extensively studied for
several decades, yet the general mechanisms controlling tRNA gene family evolution …

To further our understanding of the RNAi machinery within the human nucleus, we analyzed
the chromatin and RNA binding of Argonaute 2 (AGO2) within human cancer cell lines. Our …

Remolding of tRNAs is a well-documented process in mitochondrial genomes that changes
the identity of a tRNA. It involves a duplication of a tRNA gene, a mutation that changes the …

Analysis of RNA by deep-sequencing approaches has found widespread application in
modern biology. In addition to measurements of RNA abundance under various …