Molecular and cellular insights into T cell exhaustion
EJ Wherry, M Kurachi - Nature reviews immunology, 2015 - nature.com
In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …
inflammatory signals. This scenario is often associated with the deterioration of T cell …
Molecular and biochemical aspects of the PD-1 checkpoint pathway
VA Boussiotis - New England Journal of Medicine, 2016 - Mass Medical Soc
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
Programmed cell death–1 (PD-1) is a coinhibitory receptor that suppresses T cell activation
and is an important cancer immunotherapy target. Upon activation by its ligand PD-L1, PD-1 …
and is an important cancer immunotherapy target. Upon activation by its ligand PD-L1, PD-1 …
CD8+ T cell differentiation and dysfunction in cancer
M Philip, A Schietinger - Nature Reviews Immunology, 2022 - nature.com
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …
presence, tumours progress. The clinical success of immune checkpoint blockade and …
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment
E Peranzoni, J Lemoine, L Vimeux… - Proceedings of the …, 2018 - National Acad Sciences
In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …
Overcoming T cell exhaustion in infection and cancer
Inhibitors of the Programmed Cell Death 1: Programmed Cell Death 1 ligand 1 (PD-1: PD-
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …
Coinhibitory pathways in immunotherapy for cancer
The immune system is capable of recognizing tumors and eliminates many early malignant
cells. However, tumors evolve to evade immune attack, and the tumor microenvironment is …
cells. However, tumors evolve to evade immune attack, and the tumor microenvironment is …
Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …
must spare host tissue from harm. The fate of these cells is dictated by a series of …
CD4 T-cell exhaustion: does it exist and what are its roles in cancer?
In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
The next immune-checkpoint inhibitors: PD-1/PD-L1 blockade in melanoma
KM Mahoney, GJ Freeman, DF McDermott - Clinical therapeutics, 2015 - Elsevier
Purpose Blocking the interaction between the programmed cell death (PD)-1 protein and
one of its ligands, PD-L1, has been reported to have impressive antitumor responses …
one of its ligands, PD-L1, has been reported to have impressive antitumor responses …