CD8+ T cell differentiation and dysfunction in cancer
M Philip, A Schietinger - Nature Reviews Immunology, 2022 - nature.com
CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …
presence, tumours progress. The clinical success of immune checkpoint blockade and …
Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …
must spare host tissue from harm. The fate of these cells is dictated by a series of …
Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment
E Peranzoni, J Lemoine, L Vimeux… - Proceedings of the …, 2018 - National Acad Sciences
In a large proportion of cancer patients, CD8 T cells are excluded from the vicinity of cancer
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …
cells. The inability of CD8 T cells to reach tumor cells is considered an important mechanism …
CD4 T-cell exhaustion: does it exist and what are its roles in cancer?
In chronic infections and in cancer, persistent antigen stimulation under suboptimal
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
conditions can lead to the induction of T-cell exhaustion. Exhausted T cells are …
T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
Programmed cell death–1 (PD-1) is a coinhibitory receptor that suppresses T cell activation
and is an important cancer immunotherapy target. Upon activation by its ligand PD-L1, PD-1 …
and is an important cancer immunotherapy target. Upon activation by its ligand PD-L1, PD-1 …
Molecular and biochemical aspects of the PD-1 checkpoint pathway
VA Boussiotis - New England Journal of Medicine, 2016 - Mass Medical Soc
Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …
The immune microenvironment in pancreatic cancer
M Huber, CU Brehm, TM Gress, M Buchholz… - International journal of …, 2020 - mdpi.com
The biology of solid tumors is strongly determined by the interactions of cancer cells with
their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal …
their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal …
Molecular and cellular insights into T cell exhaustion
EJ Wherry, M Kurachi - Nature reviews immunology, 2015 - nature.com
In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …
inflammatory signals. This scenario is often associated with the deterioration of T cell …
T-cell exhaustion in chronic infections: reversing the state of exhaustion and reinvigorating optimal protective immune responses
T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
Stromal biology and therapy in pancreatic cancer: ready for clinical translation?
Pancreatic ductal adenocarcinoma (PDA) is notoriously aggressive and hard to treat. The
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …
tumour microenvironment (TME) in PDA is highly dynamic and has been found to promote …