Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …

Metabolism reprogramming is critical for both cancer progression and effective immune
responses in the tumor microenvironment. Amino acid metabolism in different cells and their …

Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-
brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport …

SLC7A5, known as LAT1, belongs to the APC superfamily and forms a heterodimeric amino
acid transporter interacting with the glycoprotein CD98 (SLC3A2) through a conserved …

Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the
release of the tumor microenvironment (TME)-specific metabolites. They create an acidic …

The L-type amino acid transporter 1 (LAT1 or SLC7A5) transports large neutral amino acids
across the membrane and is crucial for brain drug delivery and tumor growth. LAT1 forms a …

Patient-derived xenograft (PDX) models are used as powerful tools for understanding
cancer biology in PDX clinical trials and co-clinical trials. In this systematic review, we focus …

Conventional antibody–drug conjugates (ADCs) are heterogeneous mixtures of chemically
distinct molecules that vary in both drugs/antibody (DAR) and conjugation sites. Suboptimal …

The mechanism of how plant-derived nanovesicles are uptaken by cells remains unknown.
In this study, the garlic-derived nanovesicles (GDVs) were isolated and digested with trypsin …

Amplification of the MYCN oncogene is associated with an aggressive phenotype and poor
outcome in childhood neuroblastoma. Polyamines are highly regulated essential cations …