Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor, and it is
associated with poor prognosis. Its characteristics of being highly invasive and undergoing …

Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases.
Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently …

Ultrasound (US) medical technology is widely used due to its advantages of safety, speed,
and low cost. With the rapid development of biomedical nanotechnology …

Brain tumors are particularly challenging malignancies, due to their location in a structurally
and functionally distinct part of the human body–the central nervous system (CNS). The CNS …

The therapeutic management of gliomas remains particularly challenging. Brain tumors
present multiple obstacles that make therapeutic innovation complex, mainly due to the …

Focused ultrasound (FUS) in combination with microbubbles has been established as a
promising technique for noninvasive and localized Blood–brain barrier (BBB) opening. Real …

Background Despite the great potential of FUS-BBB disruption (FUS-BBBD), it is still
controversial whether FUS-BBBD acts as an inducing factor of neuro-inflammation or not …

The blood-brain barrier is the primary obstacle to efficient intracerebral drug delivery.
Focused ultrasound, in conjunction with microbubbles, is a targeted and non-invasive way to …

In spite of substantial progress made in the standard treatment and ancillary therapies that
include concurrent chemotherapy, radiotherapy, and surgery, malignant brain tumors …

The cavitation-mediated bioeffects are primarily associated with the dynamic behaviors of
bubbles in viscoelastic tissues, which involves complex interactions of cavitation bubbles …