Nutritional excess is a major forerunner of type 2 diabetes. It enhances the secretion of
insulin, but attenuates insulin's metabolic actions in the liver, skeletal muscle and adipose …

Abstract Purpose of Review This perspective is motivated by the need to question dogma
that does not work: that the problem is insulin resistance (IR). We highlight the need to …

Abstract Changes in mitochondrial morphology are associated with nutrient utilization, but
the precise causalities and the underlying mechanisms remain unknown. Here, using …

The current classification system presents challenges to the diagnosis and treatment of
patients with diabetes mellitus (DM), in part due to its conflicting and confounding definitions …

High plasma levels of fatty acids occur in a variety of metabolic diseases. Cellular effects of
fatty acid overload resulting in negative cellular responses (lipotoxicity) are often studied in …

BACKGROUND. Excessive insulin secretion may lead to glucose dysregulation. Our aim
was to identify primary (independent of insulin resistance) insulin hypersecretion in subjects …

Numerous studies have shown that oxidative stress resulting from an imbalance between
the production of free radicals and their neutralization by antioxidant enzymes is one of the …

Per-and polyfluoroalkyl substances (PFAS) are a class of environmental toxicants, and
some, such as perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) …

The pancreatic β-cell secretes insulin in response to elevated plasma glucose. This review
applies an external bioenergetic critique to the central processes of glucose-stimulated …

We hypothesize that basal hyperinsulinemia is synergistically mediated by an interplay
between increased oxidative stress and excess lipid in the form of reactive oxygen species …