Cannabinoids have numerous physiological effects. In the years since the molecular
identification of the G protein‐coupled receptors CB1 and CB2, the ion channel TRPV1, and …

The sphingosine-1-phosphate (S1P) receptor signaling system has biological and medical
importance and is the first lipid G protein–coupled receptor (GPCR) structure to be solved to …

Lysophospholipids are bioactive lipids and can signal through G-protein-coupled receptors
(GPCRs). The best studied lysophospholipids are lysophosphatidic acid (LPA) and …

Endocannabinoid system evolution was estimated by searching for functional orthologs in
the genomes of twelve phylogenetically diverse organisms: Homo sapiens, Mus musculus …

Lysophosphatidic acid (LPA, 1‐radyl‐2‐hydroxy‐sn‐glycero‐3‐phosphate) is the prototype
member of a family of lipid mediators and second messengers. LPA and its naturally …

Signal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …

Lysophosphatidic acid (LPA) is a bioactive lipid that serves as an extracellular signaling
molecule acting through cognate G protein-coupled receptors designated LPA 1–6 that …

Lysophosphatidic acid (LPA) is a ligand for LPA 1–3 of the endothelial differentiation gene
family G-protein-coupled receptors, and LPA 4–8 is related to the purinergic family G-protein …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular
functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal …

Autotaxin (ATX, nucleotide pyrophosphate/phosphodiesterase-2) is an autocrine motility
factor initially characterized from A2058 melanoma cell-conditioned medium. ATX is known …