Afonso J, Reis F–Dexmedetomidine: Current Role in Anesthesia and Intensive Care.
Background and objectives: To update and review the application of dexmedetomidine in …

Care of patients who have sustained serious burn injuries is challenging, demanding
comprehensive knowledge of the pathophysiologic perturbations that affect virtually all …

Critically ill pediatric patients often require complex medical procedures as well as invasive
testing and monitoring which tend to be painful and anxiety-provoking, necessitating the …

More than 200 studies and reports have been published regarding the use of
dexmedetomidine in infants and children. We reviewed the English literature to summarize …

Background: Dexmedetomidine is an α-2 adrenoreceptor agonist with sedative, analgesic
and anxiolytic properties. Since its release in the US market in late 1999, it has gained …

Growing and consistent preclinical evidence, combined with early clinical epidemiological
observations, suggest potentially neurotoxic effects of commonly used anesthetic agents in …

From the moment of injury through rehabilitation and beyond, pain control is a major
challenge in the management of patients with burn injuries. In fact, some argue that burn …

Most of the paediatric published studies concerning dexmedetomidine are observational in
nature, with limited control groups or comparators. Adverse effects (eg bradycardia) still …

Dexmedetomidine is being used off-label as an adjunctive agent for sedation and analgesia
in pediatric patients in the critical care unit and for sedation during non-invasive procedures …

Childhood burns are a profoundly traumatic and painful experience. Despite recognition of
the prevalence of burn injuries in children and the severity of the associated pain, burn pain …