Selection balancing at innate immune genes: Adaptive polymorphism maintenance in toll-like receptors
Balancing selection is a classic mechanism for maintaining variability in immune genes
involved in host–pathogen interactions. However, it remains unclear how widespread the …
involved in host–pathogen interactions. However, it remains unclear how widespread the …
Critical review of NGS analyses for de novo genoty** multigene families
The genoty** of highly polymorphic multigene families across many individuals used to be
a particularly challenging task because of methodological limitations associated with …
a particularly challenging task because of methodological limitations associated with …
Evolution of copy number at the MHC varies across the avian tree of life
The evolution of the major histocompatibility complex (MHC) is shaped by frequent gene
duplications and deletions, which generate extensive variation in the number of loci (gene …
duplications and deletions, which generate extensive variation in the number of loci (gene …
MHC genoty** of non-model organisms using next-generation sequencing: a new methodology to deal with artefacts and allelic dropout
Abstract Background The Major Histocompatibility Complex (MHC) is the most important
genetic marker to study patterns of adaptive genetic variation determining pathogen …
genetic marker to study patterns of adaptive genetic variation determining pathogen …
Mhc supertypes confer both qualitative and quantitative resistance to avian malaria infections in a wild bird population
Major histocompatibility complex (Mhc) genes are believed to play a key role in the genetic
basis of disease control. Although numerous studies have sought links between Mhc and …
basis of disease control. Although numerous studies have sought links between Mhc and …
A global analysis of selection at the avian MHC
Recent advancements in sequencing technology have resulted in rapid progress in the
study of the major histocompatibility complex (MHC) in non-model avian species. Here, we …
study of the major histocompatibility complex (MHC) in non-model avian species. Here, we …
The evolution of highly variable immunity genes across a passerine bird radiation
To survive, individuals must be able to recognize and eliminate pathogens. The genes of the
major histocompatibility complex (MHC) play an essential role in this process in vertebrates …
major histocompatibility complex (MHC) play an essential role in this process in vertebrates …
Extreme MHC class I diversity in the sedge warbler (Acrocephalus schoenobaenus); selection patterns and allelic divergence suggest that different genes have …
Background Recent work suggests that gene duplications may play an important role in the
evolution of immunity genes. Passerine birds, and in particular Sylvioidea warblers, have …
evolution of immunity genes. Passerine birds, and in particular Sylvioidea warblers, have …
Evolution of major histocompatibility complex gene copy number
MHC genes, which code for proteins responsible for presenting pathogen-derived antigens
to the host immune system, show remarkable copy-number variation both between and …
to the host immune system, show remarkable copy-number variation both between and …
Testing genoty** strategies for ultra‐deep sequencing of a co‐amplifying gene family: MHC class I in a passerine bird
Abstract Characterization of highly duplicated genes, such as genes of the major
histocompatibility complex (MHC), where multiple loci often co‐amplify, has until recently …
histocompatibility complex (MHC), where multiple loci often co‐amplify, has until recently …