Genomic classification of cutaneous melanoma
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …
Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X?
Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized
by the accumulation of CD 1A+/CD 207+ mononuclear phagocytes within granulomatous …
by the accumulation of CD 1A+/CD 207+ mononuclear phagocytes within granulomatous …
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance
Clinically acquired resistance to MAPK inhibitor (MAPKi) therapies for melanoma cannot be
fully explained by genomic mechanisms and may be accompanied by co-evolution of intra …
fully explained by genomic mechanisms and may be accompanied by co-evolution of intra …
Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling
E Hirata, MR Girotti, A Viros, S Hooper… - Cancer cell, 2015 - cell.com
Intravital imaging of BRAF-mutant melanoma cells containing an ERK/MAPK biosensor
reveals how the tumor microenvironment affects response to BRAF inhibition by PLX4720 …
reveals how the tumor microenvironment affects response to BRAF inhibition by PLX4720 …
Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction
Combined BRAF-and MEK-targeted therapy improves upon BRAF inhibitor (BRAFi) therapy
but is still beset by acquired resistance. We show that melanomas acquire resistance to …
but is still beset by acquired resistance. We show that melanomas acquire resistance to …
Targeting ERK beyond the boundaries of the kinase active site in melanoma
Abstract Extracellular signal‐regulated kinase 1/2 (ERK1/2) constitute a point of
convergence for complex signaling events that regulate essential cellular processes …
convergence for complex signaling events that regulate essential cellular processes …
Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination
Melanoma is difficult to treat once it becomes metastatic. However, the precise ancestral
relationship between primary tumors and their metastases is not well understood. We …
relationship between primary tumors and their metastases is not well understood. We …
Acquired Secondary RAS Mutation in BRAFV600E-Mutated Thyroid Cancer Patients Treated with BRAF Inhibitors
Background: The BRAFV600E mutation is the most common driver mutation in papillary
thyroid cancer (PTC) and anaplastic thyroid cancer (ATC). This mutation is considered …
thyroid cancer (PTC) and anaplastic thyroid cancer (ATC). This mutation is considered …
Melanoma therapeutic strategies that select against resistance by exploiting MYC-driven evolutionary convergence
Diverse pathways drive resistance to BRAF/MEK inhibitors in BRAF-mutant melanoma,
suggesting that durable control of resistance will be a challenge. By combining statistical …
suggesting that durable control of resistance will be a challenge. By combining statistical …
[HTML][HTML] ATXN1L, CIC, and ETS transcription factors modulate sensitivity to MAPK pathway inhibition
Intrinsic resistance and RTK-RAS-MAPK pathway reactivation has limited the effectiveness
of MEK and RAF inhibitors (MAPKi) in RAS-and RAF-mutant cancers. To identify genes that …
of MEK and RAF inhibitors (MAPKi) in RAS-and RAF-mutant cancers. To identify genes that …