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Self-driving laboratories for chemistry and materials science
Self-driving laboratories (SDLs) promise an accelerated application of the scientific method.
Through the automation of experimental workflows, along with autonomous experimental …
Through the automation of experimental workflows, along with autonomous experimental …
Metabolic engineering: methodologies and applications
Metabolic engineering aims to improve the production of economically valuable molecules
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
through the genetic manipulation of microbial metabolism. While the discipline is a little over …
Self-driving laboratories to autonomously navigate the protein fitness landscape
Protein engineering has nearly limitless applications across chemistry, energy and
medicine, but creating new proteins with improved or novel functions remains slow, labor …
medicine, but creating new proteins with improved or novel functions remains slow, labor …
The coming of age of AI/ML in drug discovery, development, clinical testing, and manufacturing: the FDA perspectives
SK Niazi - Drug Design, Development and Therapy, 2023 - Taylor & Francis
Artificial intelligence (AI) and machine learning (ML) represent significant advancements in
computing, building on technologies that humanity has developed over millions of years …
computing, building on technologies that humanity has developed over millions of years …
Machine learning for metabolic engineering: A review
Abstract Machine learning provides researchers a unique opportunity to make metabolic
engineering more predictable. In this review, we offer an introduction to this discipline in …
engineering more predictable. In this review, we offer an introduction to this discipline in …
Synthetic biology strategies for microbial biosynthesis of plant natural products
Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …
to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically …
Embracing nature's catalysts: a viewpoint on the future of biocatalysis
B Hauer - Acs Catalysis, 2020 - ACS Publications
Enzymes are nature's catalysts that are designed to accelerate specific reactions up to 106
times with high selectivity. 1 The enormous potential of enzymes as catalysts for organic …
times with high selectivity. 1 The enormous potential of enzymes as catalysts for organic …
Decoding catalysis by terpene synthases
JN Whitehead, NGH Leferink, LO Johannissen… - ACS …, 2023 - ACS Publications
The review by Christianson, published in 2017 on the twentieth anniversary of the
emergence of the field, summarizes the foundational discoveries and key advances in …
emergence of the field, summarizes the foundational discoveries and key advances in …
A roadmap for metagenomic enzyme discovery
SL Robinson, J Piel, S Sunagawa - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to 2021 Metagenomics has yielded massive amounts of sequencing data
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …
offering a glimpse into the biosynthetic potential of the uncultivated microbial majority. While …
Machine learning in bioprocess development: from promise to practice
Fostered by novel analytical techniques, digitalization, and automation, modern bioprocess
development provides large amounts of heterogeneous experimental data, containing …
development provides large amounts of heterogeneous experimental data, containing …