Cancer is characterized by an uncontrolled cell proliferation rate even under low nutrient
availability, which is sustained by a metabolic reprograming now recognized as a hallmark …

Innate and acquired resistances to therapeutic agents are responsible for the failure of
cancer treatments. Due to the multifactorial nature of resistance, the identification of new …

Background: Thyroid cancer is the most common endocrine tumor. Our previous studies
have demonstrated that curcumin can induce apoptosis in human papillary thyroid …

Inter-organelle membrane contact sites are emerging as major sites for the regulation of
intracellular Ca2+ concentration and distribution. Here, extracellular stimuli operate on a …

Diabetes mellitus (DM) is on the rise, necessitating the development of novel therapeutic
and preventive strategies to mitigate the disease's debilitating effects. Diabetic …

Pachymic acid has various pharmacological effects, including anti‐inflammatory,
antioxidant, immunomodulatory, and antitumor. However, the role of pachymic acid in …

Iezoside (1a) is a novel, potent sarco-/endoplasmic reticulum Ca2+ ATPase (SERCA)
inhibitor from marine cyanobacterium. This paper describes the synthesis of comprehensive …

Intracellular calcium (Ca2+) concentration ([Ca2+] i) is implicated in proliferation, invasion,
and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate …

Background Inactivation of tumor suppressor genes by promoter hypermethylation plays a
key role in the tumorgenesis. It is necessary to uncover the detailed pattern of whole …

Myocardial infarction and revascularization cause cardiac ischemia/reperfusion (I/R) injury
featuring cardiomyocyte death and inflammation. The Ca 2+/calmodulin dependent protein …