Recent progress in retinal pigment epithelium cell-based therapy for retinal disease

V Klymenko, OG González Martínez… - Stem Cells …, 2024 - academic.oup.com
Age-related macular degeneration and retinitis pigmentosa are degenerative retinal
diseases that cause severe vision loss. Early clinical trials involving transplantation of retinal …

Stem cell culture and differentiation in 3-D scaffolds

Y Tabata, I Joanna, A Higuchi - Progress in Molecular Biology and …, 2023 - Elsevier
Abstract Conventional two-dimensional (2-D) cultivation are easy to utilize for human
pluripotent stem (hPS) cell cultivation in standard techniques and are important for analysis …

Preparation of thermosensitive PNIPAm-based copolymers with tertiary amino and hydroxyl monomer for cell attachment and detachment study

CFJ Kuo, CJ Mei, CC Huang, XT Lin, TY Wu… - European Polymer …, 2023 - Elsevier
Thermo-responsive microcarriers are essential for large-scale expansion of anchorage-
dependent cells in a suspension culture. In this study, the authors prepared four different N …

Cell Adhesion and Local Cytokine Control on Protein‐Functionalized PNIPAM‐co‐AAc Hydrogel Microcarriers

SB Rauer, L Stüwe, L Steinbeck, MAS de Toledo… - Small, 2025 - Wiley Online Library
Achieving adequate cell densities remains a major challenge in establishing economic
biotechnological and biomedical processes. A possible remedy is microcarrier‐based …

Effects of ECM protein-coated surfaces on the generation of retinal pigment epithelium cells differentiated from human pluripotent stem cells

Z Tian, Q Liu, HY Lin, YR Zhu, L Ling… - Regenerative …, 2024 - academic.oup.com
Retinal degeneration diseases, such as age-related macular degeneration (AMD) and
retinitis pigmentosa (RP), initially manifest as dysfunction or death of the retinal pigment …

Gene and cell-based therapies for retinal and optic nerve disease

EP Esposito, IC Han, TV Johnson - Handbook of Clinical Neurology, 2024 - Elsevier
Leading causes of blindness worldwide include neurodegenerative diseases of the retina,
which cause irreversible loss of retinal pigment epithelium (RPE) and photoreceptors, and …