Aurora B, a member of the Aurora family of serine/threonine protein kinases, is a key player
in chromosome segregation. As part of a macromolecular complex known as the …

More than a hundred proteins comprise the RAS superfamily of small GTPases. This family
can be divided into RAS, RHO, RAB, RAN, ARF, and RAD subfamilies, with each shown to …

Cutaneous melanoma is very aggressive and results in high mortality rates for cancer
patients. Determining molecular targets is important for develo** novel therapies for …

Cell cycle and cell adhesion are two interdependent cellular processes regulating each
other, reciprocally, in every cell cycle phase. The cell adhesion to the extracellular matrix …

Weighted gene co-expression network analysis (WGCNA) identified a cell-cycle module that
is associated with poor prognosis and aggressiveness of glioma. One of the core members …

Purpose: Investigate the role of regulator of chromosome condensation 2 (RCC2) on lung
adenocarcinoma (LUAD) metastasis. Experimental Design: Clinical specimens were used to …

In recent years, long non-coding RNA (lncRNA) research has identified essential roles of
these transcripts in virtually all physiological cellular processes including tumorigenesis, but …

RALA and RALB are highly homologous small G proteins belonging to the RAS superfamily.
Like other small GTPases, the RALs are molecular switches that can be toggled between …

Cytokinesis is required for faithful division of cytoplasmic components and duplicated nuclei
into two daughter cells. Midbody, a protein-dense organelle that forms at the intercellular …

Although the small GTPase RAB37 acts as an organizer of autophagosome biogenesis, the
upstream regulatory mechanism of autophagy via guanosine diphosphate (GDP)-guanosine …