Biopharmaceuticals have emerged to play a vital role in disease treatment and have shown
promise in the rapidly expanding pharmaceutical market due to their high specificity and …

Biomacromolecules have long been at the leading edge of academic and pharmaceutical
drug development and clinical translation. With the clinical advances of new therapeutics …

The delivery of functional proteins remains a major challenge in advancing biological and
pharmaceutical sciences. Herein, we describe a powerful, simple, and highly effective …

Cytosolic delivery of peptides remains a challenging task because of the limited binding
sites on peptides and the existence of multiple intracellular barriers. Here, we proposed the …

The number of protein-based drugs is exponentially increasing. However, development of
protein therapeutics against intracellular targets is hampered by the lack of efficient cytosolic …

Engineering of smart building molecules is key basis in designing intelligent drug delivery
systems. As an emerging sophisticated delivery system strategy, the powerful functions of …

The treatment of breast cancer relies heavily on chemotherapy, but chemotherapy is limited
by the disadvantages of poor targeting, susceptibility to extracellular matrix (ECM) …

Cell penetrating peptides (CPPs) can be broadly defined as relatively short synthetic, protein
derived or chimeric peptides. Their most remarkable property is their ability to cross cell …

Recently, membrane-active peptides or proteins that include antimicrobial peptides (AMPs),
cytolytic proteins, and cell-penetrating peptides (CPPs) have attracted attention due to their …

The combination of chemotherapy and protein therapy holds immense promise for tumor
treatment. However, conventional bolus formulation or simple co-administration fails to …