[HTML][HTML] Nanopore sequencing and its application to the study of microbial communities

L Ciuffreda, H Rodríguez-Pérez, C Flores - Computational and structural …, 2021 - Elsevier
Since its introduction, nanopore sequencing has enhanced our ability to study complex
microbial samples through the possibility to sequence long reads in real time using …

[HTML][HTML] A review of computational tools for generating metagenome-assembled genomes from metagenomic sequencing data

C Yang, D Chowdhury, Z Zhang, WK Cheung… - Computational and …, 2021 - Elsevier
Metagenomic sequencing provides a culture-independent avenue to investigate the
complex microbial communities by constructing metagenome-assembled genomes (MAGs) …

American gut: an open platform for citizen science microbiome research

D McDonald, E Hyde, JW Debelius, JT Morton… - Msystems, 2018 - Am Soc Microbiol
Although much work has linked the human microbiome to specific phenotypes and lifestyle
variables, data from different projects have been challenging to integrate and the extent of …

Alzheimer's disease microbiome is associated with dysregulation of the anti-inflammatory P-glycoprotein pathway

JP Haran, SK Bhattarai, SE Foley, P Dutta, DV Ward… - MBio, 2019 - Am Soc Microbiol
The microbiota-gut-brain axis is a bidirectional communication system that is poorly
understood. Alzheimer's disease (AD), the most common cause of dementia, has long been …

Exploring bacterial diversity via a curated and searchable snapshot of archived DNA sequences

GA Blackwell, M Hunt, KM Malone, L Lima… - PLoS …, 2021 - journals.plos.org
The open sharing of genomic data provides an incredibly rich resource for the study of
bacterial evolution and function and even anthropogenic activities such as the widespread …

Enrichment of oral-derived bacteria in inflamed colorectal tumors and distinct associations of Fusobacterium in the mesenchymal subtype

BS Younginger, O Mayba, J Reeder, DR Nagarkar… - Cell Reports …, 2023 - cell.com
While the association between colorectal cancer (CRC) features and Fusobacterium has
been extensively studied, less is known of other intratumoral bacteria. Here, we leverage …

Species-resolved sequencing of low-biomass or degraded microbiomes using 2bRAD-M

Z Sun, S Huang, P Zhu, L Tzehau, H Zhao, J Lv… - Genome biology, 2022 - Springer
Microbiome samples with low microbial biomass or severe DNA degradation remain
challenging for amplicon-based or whole-metagenome sequencing approaches. Here, we …

Discovery of disease-adapted bacterial lineages in inflammatory bowel diseases

A Kumbhari, TNH Cheng, AN Ananthakrishnan… - Cell Host & Microbe, 2024 - cell.com
Gut bacteria are implicated in inflammatory bowel disease (IBD), but the strains driving these
associations are unknown. Large-scale studies of microbiome evolution could reveal the …

[HTML][HTML] Unprecedented Harmful algal bloom in the UK and Ireland's largest lake associated with gastrointestinal bacteria, microcystins and anabaenopeptins …

N Reid, MI Reyne, W O'Neill, B Greer, Q He… - Environment …, 2024 - Elsevier
Abstract Harmful Algal Blooms (HABs) are outbreaks of aquatic toxic microalgae emerging
as a global problem driven by nutrient enrichment, global climate change and invasive …

Phylogeny-aware analysis of metagenome community ecology based on matched reference genomes while bypassing taxonomy

Q Zhu, S Huang, A Gonzalez, I McGrath, D McDonald… - Msystems, 2022 - Am Soc Microbiol
We introduce the operational genomic unit (OGU) method, a metagenome analysis strategy
that directly exploits sequence alignment hits to individual reference genomes as the …