[HTML][HTML] Unraveling the versatility of human serum albumin–A comprehensive review of its biological significance and therapeutic potential
Human serum albumin (HSA) is a multi-domain macromolecule with diverse ligand binding
capability because of its ability to allow allosteric modulation despite being a monomeric …
capability because of its ability to allow allosteric modulation despite being a monomeric …
[HTML][HTML] Metallodrug binding to serum albumin: Lessons from biophysical and structural studies
A Merlino - Coordination Chemistry Reviews, 2023 - Elsevier
Human serum albumin (HSA) plays a major role in the transport of metallodrugs, affecting
pharmacokinetics and pharmacodynamics of these molecules. This work highlights the …
pharmacokinetics and pharmacodynamics of these molecules. This work highlights the …
Evaluation of in vitro distribution and plasma protein binding of selected antiviral drugs (favipiravir, molnupiravir and imatinib) against SARS-CoV-2
There are a number of uncertainties regarding plasma protein binding and blood distribution
of the active drugs favipiravir (FAVI), molnupiravir (MOLNU) and imatinib (IMA), which were …
of the active drugs favipiravir (FAVI), molnupiravir (MOLNU) and imatinib (IMA), which were …
A comparative study of novel ruthenium (III) and iron (III) complexes containing uracil; docking and biological studies
Structural and biological studies were conducted on the novel complexes [Fe (U) 2 (H 2 O)
2] Cl 3 (FeU) and [Ru (U) 2 (H 2 O) 2] Cl 3 (RuU)(U= 5, 6-Diamino-1, 3-dimethylpyrimidine-2 …
2] Cl 3 (FeU) and [Ru (U) 2 (H 2 O) 2] Cl 3 (RuU)(U= 5, 6-Diamino-1, 3-dimethylpyrimidine-2 …
Ruthenium (II)-diphosphine complexes containing acylthiourea ligands are effective against lung and breast cancers
We have synthesized and characterized three new ruthenium (II) diphosphine complexes
containing an acylthiourea ligand, with the general formula [Ru (DPEPhos)(O, S)(bipy)] PF6 …
containing an acylthiourea ligand, with the general formula [Ru (DPEPhos)(O, S)(bipy)] PF6 …
Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile
C Wittmann, F Bacher, EA Enyedy… - Journal of Medicinal …, 2022 - ACS Publications
A series of latonduine and indoloquinoline derivatives HL1–HL8 and their copper (II)
complexes (1–8) were synthesized and comprehensively characterized. The structures of …
complexes (1–8) were synthesized and comprehensively characterized. The structures of …
One-pot hydrothermal synthesis of a mononuclear cobalt (II) complex and an organic-inorganic supramolecular adduct: Structures, properties and hirshfeld surface …
JX Li, YQ **a, LM Cheng, X Feng - Journal of Solid State Chemistry, 2022 - Elsevier
Through the hydrothermal reaction of cobalt (II) perchlorate hexahydrate with 5-bromo-6-
methyl-pyridine-2-carboxylic acid (5-Br-6-Me-Hpyc) and 1, 4-bis (4-pyridyl) benzene (1, 4 …
methyl-pyridine-2-carboxylic acid (5-Br-6-Me-Hpyc) and 1, 4-bis (4-pyridyl) benzene (1, 4 …
Metal complexes of a 5-nitro-8-hydroxyquinoline-proline hybrid with enhanced water solubility targeting multidrug resistant cancer cells
Multidrug resistance (MDR) in cancer is one of the major obstacles of chemotherapy. We
have recently identified a series of 8-hydroxyquinoline Mannich base derivatives with MDR …
have recently identified a series of 8-hydroxyquinoline Mannich base derivatives with MDR …
Enhancing Bioactivity of N,N,N-Chelating Rhodium(III) Complexes with Ionic Liquids: Toward Targeted Cancer Therapy
A Caković, D Ćoćić, M Živanović… - Journal of Medicinal …, 2024 - ACS Publications
This study investigates the potential of using ionic liquids as cosolvents to enhance the
solubility and activity of poorly soluble rhodium (III) complexes, particularly those with diene …
solubility and activity of poorly soluble rhodium (III) complexes, particularly those with diene …
Indolo [2, 3-e] benzazocines and indolo [2, 3-f] benzazonines and their copper (II) complexes as microtubule destabilizing agents
C Wittmann, O Dömötör, I Kuznetcova, G Spengler… - Dalton …, 2023 - pubs.rsc.org
A series of four indolo [2, 3-e] benzazocines HL1–HL4 and two indolo [2, 3-f] benzazonines
HL5 and HL6, as well as their respective copper (II) complexes 1–6, were synthesized and …
HL5 and HL6, as well as their respective copper (II) complexes 1–6, were synthesized and …