[HTML][HTML] Unraveling the versatility of human serum albumin–A comprehensive review of its biological significance and therapeutic potential

S Ashraf, H Qaiser, S Tariq, A Khalid… - Current Research in …, 2023 - Elsevier
Human serum albumin (HSA) is a multi-domain macromolecule with diverse ligand binding
capability because of its ability to allow allosteric modulation despite being a monomeric …

[HTML][HTML] Metallodrug binding to serum albumin: Lessons from biophysical and structural studies

A Merlino - Coordination Chemistry Reviews, 2023 - Elsevier
Human serum albumin (HSA) plays a major role in the transport of metallodrugs, affecting
pharmacokinetics and pharmacodynamics of these molecules. This work highlights the …

Evaluation of in vitro distribution and plasma protein binding of selected antiviral drugs (favipiravir, molnupiravir and imatinib) against SARS-CoV-2

O Dömötör, ÉA Enyedy - International Journal of Molecular Sciences, 2023 - mdpi.com
There are a number of uncertainties regarding plasma protein binding and blood distribution
of the active drugs favipiravir (FAVI), molnupiravir (MOLNU) and imatinib (IMA), which were …

A comparative study of novel ruthenium (III) and iron (III) complexes containing uracil; docking and biological studies

F Althobaiti, HA Sahyon, MMAH Shanab… - Journal of Inorganic …, 2023 - Elsevier
Structural and biological studies were conducted on the novel complexes [Fe (U) 2 (H 2 O)
2] Cl 3 (FeU) and [Ru (U) 2 (H 2 O) 2] Cl 3 (RuU)(U= 5, 6-Diamino-1, 3-dimethylpyrimidine-2 …

Ruthenium (II)-diphosphine complexes containing acylthiourea ligands are effective against lung and breast cancers

GF Grawe, KM Oliveira, CM Leite, TD de Oliveira… - Dalton …, 2022 - pubs.rsc.org
We have synthesized and characterized three new ruthenium (II) diphosphine complexes
containing an acylthiourea ligand, with the general formula [Ru (DPEPhos)(O, S)(bipy)] PF6 …

Highly Antiproliferative Latonduine and Indolo[2,3-c]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile

C Wittmann, F Bacher, EA Enyedy… - Journal of Medicinal …, 2022 - ACS Publications
A series of latonduine and indoloquinoline derivatives HL1–HL8 and their copper (II)
complexes (1–8) were synthesized and comprehensively characterized. The structures of …

One-pot hydrothermal synthesis of a mononuclear cobalt (II) complex and an organic-inorganic supramolecular adduct: Structures, properties and hirshfeld surface …

JX Li, YQ **a, LM Cheng, X Feng - Journal of Solid State Chemistry, 2022 - Elsevier
Through the hydrothermal reaction of cobalt (II) perchlorate hexahydrate with 5-bromo-6-
methyl-pyridine-2-carboxylic acid (5-Br-6-Me-Hpyc) and 1, 4-bis (4-pyridyl) benzene (1, 4 …

Metal complexes of a 5-nitro-8-hydroxyquinoline-proline hybrid with enhanced water solubility targeting multidrug resistant cancer cells

T Pivarcsik, V Pósa, H Kovács, NV May… - International Journal of …, 2022 - mdpi.com
Multidrug resistance (MDR) in cancer is one of the major obstacles of chemotherapy. We
have recently identified a series of 8-hydroxyquinoline Mannich base derivatives with MDR …

Enhancing Bioactivity of N,N,N-Chelating Rhodium(III) Complexes with Ionic Liquids: Toward Targeted Cancer Therapy

A Caković, D Ćoćić, M Živanović… - Journal of Medicinal …, 2024 - ACS Publications
This study investigates the potential of using ionic liquids as cosolvents to enhance the
solubility and activity of poorly soluble rhodium (III) complexes, particularly those with diene …

Indolo [2, 3-e] benzazocines and indolo [2, 3-f] benzazonines and their copper (II) complexes as microtubule destabilizing agents

C Wittmann, O Dömötör, I Kuznetcova, G Spengler… - Dalton …, 2023 - pubs.rsc.org
A series of four indolo [2, 3-e] benzazocines HL1–HL4 and two indolo [2, 3-f] benzazonines
HL5 and HL6, as well as their respective copper (II) complexes 1–6, were synthesized and …