Coding principles in adaptation

AI Weber, K Krishnamurthy… - Annual review of vision …, 2019 - annualreviews.org
Adaptation is a common principle that recurs throughout the nervous system at all stages of
processing. This principle manifests in a variety of phenomena, from spike frequency …

Analysis of neuronal spike trains, deconstructed

J Aljadeff, BJ Lansdell, AL Fairhall, D Kleinfeld - Neuron, 2016 - cell.com
As information flows through the brain, neuronal firing progresses from encoding the world
as sensed by the animal to driving the motor output of subsequent behavior. One of the more …

Multiplexed spike coding and adaptation in the thalamus

RA Mease, T Kuner, AL Fairhall, A Groh - Cell reports, 2017 - cell.com
High-frequency" burst" clusters of spikes are a generic output pattern of many neurons.
While bursting is a ubiquitous computational feature of different nervous systems across …

The role of adaptation in neural coding

AI Weber, AL Fairhall - Current opinion in neurobiology, 2019 - Elsevier
Highlights•Simple models, both statistical and dynamical, can exhibit a variety of adaptive
phenomena without the need for a change in parameters.•More complex models such as …

Multiple timescales account for adaptive responses across sensory cortices

KW Latimer, D Barbera, M Sokoletsky… - Journal of …, 2019 - Soc Neuroscience
Sensory systems encounter remarkably diverse stimuli in the external environment. Natural
stimuli exhibit timescales and amplitudes of variation that span a wide range. Mechanisms of …

Enhanced sensitivity to rapid input fluctuations by nonlinear threshold dynamics in neocortical pyramidal neurons

S Mensi, O Hagens, W Gerstner… - PLoS computational …, 2016 - journals.plos.org
The way in which single neurons transform input into output spike trains has fundamental
consequences for network coding. Theories and modeling studies based on standard …

Intrinsic neuronal properties switch the mode of information transmission in networks

J Gjorgjieva, RA Mease, WJ Moody… - PLoS computational …, 2014 - journals.plos.org
Diverse ion channels and their dynamics endow single neurons with complex biophysical
properties. These properties determine the heterogeneity of cell types that make up the …

FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems

G Qi, D Yang, F Messore, A Bast, F Yáñez… - Iscience, 2025 - cell.com
Summary The FOXP2/Foxp2 gene, linked to fine motor control in vertebrates, is a potential
candidate gene thought to play a prominent role in human language production. It is …

Predicting responses to inhibitory synaptic input in substantia nigra pars reticulata neurons

DV Simmons, MH Higgs, S Lebby… - Journal of …, 2018 - journals.physiology.org
The changes in firing probability produced by a synaptic input are usually visualized using
the poststimulus time histogram (PSTH). It would be useful if postsynaptic firing patterns …

Capturing multiple timescales of adaptation to second-order statistics with generalized linear models: gain scaling and fractional differentiation

KW Latimer, AL Fairhall - Frontiers in systems neuroscience, 2020 - frontiersin.org
Single neurons can dynamically change the gain of their spiking responses to take into
account shifts in stimulus variance. Moreover, gain adaptation can occur across multiple …