Halfway through the twentieth century, fluoride piqued the interest of toxicologists due to its
deleterious effects at high concentrations in human populations suffering from fluorosis and …

Astroglia possess excitability based on movements of Ca2+ ions between intracellular
compartments and plasmalemmal Ca2+ fluxes. This “Ca2+ excitability” is controlled by …

Synucleinopathies, such as Parkinson's disease and dementia with Lewy bodies, are
neurodegenerative disorders that are characterized by the accumulation of α-synuclein …

Synaptic dysfunction plays a central role in Alzheimer's disease (AD), since it drives the
cognitive decline. An association between a polymorphism of the adenosine A2A receptor …

Ca2+ is a universal second messenger controlling a wide variety of cellular reactions and
adaptive responses. The initial appreciation of Ca2+ as a universal signalling molecule was …

To the Editor—The recent breakthroughs in the development of optical nanoscopy have
provided unprecedented views of the inner workings of cells. Stimulated emission depletion …

Alternans of cardiac repolarization is associated with arrhythmias and sudden death. At the
cellular level, alternans involves beat-to-beat oscillation of the action potential (AP) and …

The past several decades of research into calcium signaling have focused on intracellular
calcium (Cai2+), revealing both exquisite spatial and dynamic control of this potent second …

The development of the calcium signalling field, from its early beginnings some 40 years
ago to the present, is described. Calcium signalling in exocrine gland acinar cells and the …

Background and objective Ever since its discovery, calcium imaging has proven its worth in
discovering new insights into the mechanisms of cellular communication. Yet, the analysis of …