This guideline presents recommendations for the management of patients with hereditary
gastrointestinal cancer syndromes. The initial assessment is the collection of a family history …

Colorectal carcinoma is one of the most common cancers and one of the leading causes of
cancer-related death in the United States. Pathologic examination of biopsy, polypectomy …

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost
30% of the population in the UK have a family history of CRC. The quantification of an …

Colorectal cancer (CRC) is a very heterogeneous disease that is caused by the interaction
of genetic and environmental factors. CRC develops through a gradual accumulation of …

Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

This book is the third volume of the 4th Edition of the WHO series on histological and genetic
ty** of human tumours. It is an authoritative, concise reference book providing an …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

The British Society of Gastroenterology (BSG) and the Association of Coloproctology for
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …

Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a
constant challenge for living organisms. Base-excision repair has an important role in …

Familial adenomatous polyposis (FAP) is an autosomal-dominant colorectal cancer
syndrome, caused by a germline mutation in the adenomatous polyposis coli (APC) gene …