The peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play key
roles in the regulation of lipid metabolism, inflammation, cellular growth, and differentiation …

The last few years have witnessed a rapid increase in our knowledge of the retinoid-related
orphan receptors RORα,-β, and-γ (NR1F1-3), their mechanism of action, physiological …

Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone
binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal …

Nuclear receptor pharmacology has, to a certain extent, led the way, compared with other
receptor systems, in the appreciation that ligands may exert very diverse pharmacology …

586 contains two highly conserved zincfingers–C-X2-C-X13-C-X2-C and CX5-C-X9-C-X2-C–
the four cysteines of each finger chelating one Zn2+ ion. The structure represented shows …

Nuclear receptors are ancient ligand-regulated transcription factors that control key
metabolic and developmental pathways. The fruitfly Drosophila melanogaster has only 18 …

Mechanisms that protect the body from a diverse array of harmful chemicals are also
involved in drug metabolism, and can cause adverse drug–drug interactions. Two closely …

Insecticide induced-hormesis, a bi-phasic phenomenon characterized by low dose
stimulation and high dose inhibition following exposure to insecticide, is crucial to insect …

Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with
classic nuclear receptor domain structure lacking identified signaling ligands are designated …

The biology of peroxisome proliferator activated receptors (PPARs) in physiological and
pathophysiological processes has been primarily studied in peripherial organs and tissues …