Noncoding RNA s in disease

E Lekka, J Hall - FEBS letters, 2018 - Wiley Online Library
Noncoding RNA s are emerging as potent and multifunctional regulators in all biological
processes. In parallel, a rapidly growing number of studies has unravelled associations …

Molecular basis of familial and sporadic Alzheimer's disease

J Dorszewska, M Prendecki… - Current Alzheimer …, 2016 - benthamdirect.com
Alzheimer's disease (AD) is a multifactorial disease with genetic (70%) and environmental
(30%) causes. Among the genetic factors are genes associated with a family history of the …

The epigenetics of aging and neurodegeneration

R Lardenoije, A Iatrou, G Kenis, K Kompotis… - Progress in …, 2015 - Elsevier
Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

microRNAs in Parkinson's disease: from pathogenesis to novel diagnostic and therapeutic approaches

L Leggio, S Vivarelli, F L'Episcopo, C Tirolo… - International journal of …, 2017 - mdpi.com
Parkinson's disease (PD) is the most prevalent central nervous system (CNS) movement
disorder and the second most common neurodegenerative disease overall. PD is …

Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of …

K Burgos, I Malenica, R Metpally, A Courtright… - PloS one, 2014 - journals.plos.org
The discovery and reliable detection of markers for neurodegenerative diseases have been
complicated by the inaccessibility of the diseased tissue-such as the inability to biopsy or …

MicroRNAs as modulators of longevity and the aging process

HE Kinser, Z Pincus - Human genetics, 2020 - Springer
MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally repress
translation or induce mRNA degradation of target transcripts through sequence-specific …

MicroRNAs and their roles in aging

T Smith-Vikos, FJ Slack - Journal of cell science, 2012 - journals.biologists.com
MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind mRNAs through partial
base-pair complementarity with their target genes, resulting in post-transcriptional …

The p53/miR-34 axis in development and disease

M Rokavec, H Li, L Jiang… - Journal of molecular cell …, 2014 - academic.oup.com
The tumor suppressor p53 is one of the most frequently mutated genes in human cancers.
MicroRNAs (miRNAs) are small non-protein coding RNAs that regulate gene expression on …

Micro RNA‐125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

J Banzhaf‐Strathmann, E Benito, S May… - The EMBO …, 2014 - embopress.org
Sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but no clear
disease‐initiating mechanism is known. Aβ deposits and neuronal tangles composed of …

Nutrigenomics of extra‐virgin olive oil: A review

M Piroddi, A Albini, R Fabiani, L Giovannelli… - Biofactors, 2017 - Wiley Online Library
Nutrigenomics data on the functional components of olive oil are still sparse, but rapidly
increasing. Olive oil is the main source of fat and health‐promoting component of the …