Fifty shades of brain: a review on the mechanical testing and modeling of brain tissue

S Budday, TC Ovaert, GA Holzapfel… - … Methods in Engineering, 2020 - Springer
Brain tissue is not only one of the most important but also the most complex and compliant
tissue in the human body. While long underestimated, increasing evidence confirms that …

Viscoelastic cell microenvironment: hydrogel‐based strategy for recapitulating dynamic ECM mechanics

Y Ma, T Han, Q Yang, J Wang, B Feng… - Advanced Functional …, 2021 - Wiley Online Library
The native extracellular matrix (ECM) generally exhibits dynamic mechanical properties and
displays time‐dependent responses to deformation or mechanical loading, in terms of …

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

G Seano, HT Nia, KE Emblem, M Datta, J Ren… - Nature biomedical …, 2019 - nature.com
The compression of brain tissue by a tumour mass is believed to be a major cause of the
clinical symptoms seen in patients with brain cancer. However, the biological consequences …

Mechanical map** of spinal cord growth and repair in living zebrafish larvae by Brillouin imaging

R Schlüßler, S Möllmert, S Abuhattum, G Cojoc… - Biophysical journal, 2018 - cell.com
The mechanical properties of biological tissues are increasingly recognized as important
factors in developmental and pathological processes. Most existing mechanical …

Nanoindentation of soft biological materials

L Qian, H Zhao - Micromachines, 2018 - mdpi.com
Nanoindentation techniques, with high spatial resolution and force sensitivity, have recently
been moved into the center of the spotlight for measuring the mechanical properties of …

Mechanobiology of the brain in ageing and Alzheimer's disease

CM Hall, E Moeendarbary… - European Journal of …, 2021 - Wiley Online Library
Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …

The shrinking brain: cerebral atrophy following traumatic brain injury

TC Harris, R De Rooij, E Kuhl - Annals of biomedical engineering, 2019 - Springer
Cerebral atrophy in response to traumatic brain injury is a well-documented phenomenon in
both primary investigations and review articles. Recent atrophy studies focus on exploring …

Arterial pulsations drive oscillatory flow of CSF but not directional pum**

RT Kedarasetti, PJ Drew, F Costanzo - Scientific reports, 2020 - nature.com
The brain lacks a traditional lymphatic system for metabolite clearance. The existence of a
“glymphatic system” where metabolites are removed from the brain's extracellular space by …

Tissue-engineered blood-brain barrier models via directed differentiation of human induced pluripotent stem cells

GN Grifno, AM Farrell, RM Linville, D Arevalo, JH Kim… - Scientific reports, 2019 - nature.com
Abstract Three-dimensional (3D) tissue-engineered models of the blood-brain barrier (BBB)
recapitulate in vivo shear stress, cylindrical geometry, and cell-ECM interactions. Here we …

Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model

RT Kedarasetti, PJ Drew, F Costanzo - Fluids and Barriers of the CNS, 2022 - Springer
The movement of fluid into, through, and out of the brain plays an important role in clearing
metabolic waste. However, there is controversy regarding the mechanisms driving fluid …