Preeclampsia (PE) is a multisystem heterogeneous complication of pregnancy remaining a
leading cause of maternal and perinatal morbidity and mortality over the world. PE has a …

The initial report that cellular prion protein (PrP C) mediates toxicity of amyloid-β species
linked to Alzheimer's disease was initially treated with scepticism, but growing evidence …

Co-aggregation of multiple pathogenic proteins is common in neurodegenerative diseases
but deconvolution of such biochemical process is challenging. Herein, we developed a dual …

Despite extensive study, progress in elucidation of biological functions of amyloids and their
role in pathology is largely restrained due to the lack of universal and reliable biochemical …

Amyloids are unbranched protein fibrils with a characteristic spatial structure. Although the
amyloids were first described as protein deposits that are associated with the diseases …

Amyloids are fibrous cross-β protein aggregates that are capable of proliferation via
nucleated polymerization. Amyloid conformation likely represents an ancient protein fold …

Fibrous cross-β aggregates (amyloids) and their transmissible forms (prions) cause
diseases in mammals (including humans) and control heritable traits in yeast. Initial …

Background: It is estimated that the average time between the diagnosis of Alzheimer's
disease (AD) and the patient's death is 5-9 years. Therefore, both the initial phase of the …

Förster resonance energy transfer (FRET) microscopy is a powerful fluorescence
microscopy method to study the nanoscale organization of multiprotein assemblies in vivo …

Alzheimer's disease (AD) is an age-related, multifaceted neurological disorder associated
with accumulation of aggregated proteins (amyloid Aβ and hyperphosphorylated tau), loss of …