Cytokine‐and chemokine‐induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy

AA Bhat, S Nisar, M Singh, B Ashraf… - Cancer …, 2022 - Wiley Online Library
Colorectal cancer (CRC) is a predominant life‐threatening cancer, with liver and peritoneal
metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor …

Chemokines in colon cancer progression

SN Jia, YB Han, R Yang, ZC Yang - Seminars in Cancer Biology, 2022 - Elsevier
Colon cancer is a major human cancer accounting for about a tenth of all cancer cases thus
making it among the top three cancers in terms of incidence as well as mortality. Metastasis …

Role of VEGFs/VEGFR-1 signaling and its inhibition in modulating tumor invasion: experimental evidence in different metastatic cancer models

C Ceci, MG Atzori, PM Lacal, G Graziani - International journal of …, 2020 - mdpi.com
The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

[HTML][HTML] Wnt/β-catenin signalling, epithelial-mesenchymal transition and crosslink signalling in colorectal cancer cells

L Sun, J **ng, X Zhou, X Song, S Gao - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Colorectal cancer (CRC), with its significant incidence and metastatic rates, profoundly
affects human health. A common oncogenic event in CRC is the aberrant activation of the …

[HTML][HTML] Exploring the role of the gut and intratumoral microbiomes in tumor progression and metastasis

A Sevcikova, B Mladosievicova, M Mego… - International journal of …, 2023 - mdpi.com
Cancer cell dissemination involves invasion, migration, resistance to stressors in the
circulation, extravasation, colonization, and other functions responsible for macroscopic …

[HTML][HTML] Ferroptosis-based nano delivery systems targeted therapy for colorectal cancer: insights and future perspectives

C Qiao, H Wang, Q Guan, M Wei, Z Li - Asian Journal of Pharmaceutical …, 2022 - Elsevier
There are limited options for patients who develop liver metastasis from colorectal cancer
(CRC), the leading cause of cancer-related mortality worldwide. Emerging evidence has …

Molecular features and gene expression signature of metastatic colorectal cancer

M Poturnajova, T Furielova, S Balintova… - Oncology …, 2021 - spandidos-publications.com
Uncontrollable metastatic outgrowth process is the leading cause of mortality worldwide,
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …

Current applications and future directions of circulating tumor cells in colorectal cancer recurrence

KY Tsai, PS Huang, PY Chu, TNA Nguyen, HY Hung… - Cancers, 2024 - mdpi.com
Simple Summary The ability to predict or detect colorectal cancer (CRC) recurrence early
after surgery enables physicians to apply appropriate treatment plans and different follow-up …

LNA-i-miR-221 activity in colorectal cancer: a reverse translational investigation

A Ali, K Grillone, S Ascrizzi, G Caridà, L Fiorillo… - … Therapy-Nucleic Acids, 2024 - cell.com
Colorectal cancer (CRC) is one of the most common malignancies and a relevant cause of
cancer-related deaths worldwide. Dysregulation of microRNA (miRNA) expression has been …

MicroRNA‐124‐3p suppresses PD‐L1 expression and inhibits tumorigenesis of colorectal cancer cells via modulating STAT3 signaling

E Roshani Asl, Y Rasmi… - Journal of cellular …, 2021 - Wiley Online Library
Programmed death ligand 1 (PD‐L1) plays a significant role in colorectal tumorigenesis
through induction of regulatory T cells (Tregs) and suppression of antitumor immunity …