Control of protein stability by post-translational modifications
Post-translational modifications (PTMs) can occur on specific amino acids localized within
regulatory domains of target proteins, which control a protein's stability. These regions …
regulatory domains of target proteins, which control a protein's stability. These regions …
Technical challenges of working with extracellular vesicles
Extracellular Vesicles (EVs) are gaining interest as central players in liquid biopsies, with
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …
potential applications in diagnosis, prognosis and therapeutic guidance in most pathological …
Direct observation of glycans bonded to proteins and lipids at the single-molecule level
Proteins and lipids decorated with glycans are found throughout biological entities, playing
roles in biological functions and dysfunctions. Current analytical strategies for these glycan …
roles in biological functions and dysfunctions. Current analytical strategies for these glycan …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
The growing landscape of lysine acetylation links metabolism and cell signalling
Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
Lysine acetylation targets protein complexes and co-regulates major cellular functions
Lysine acetylation is a reversible posttranslational modification of proteins and plays a key
role in regulating gene expression. Technological limitations have so far prevented a global …
role in regulating gene expression. Technological limitations have so far prevented a global …
[HTML][HTML] Precision map** of an in vivo N-glycoproteome reveals rigid topological and sequence constraints
N-linked glycosylation is a biologically important protein modification, but only a small
fraction of modification sites have been mapped. We developed a" filter aided sample …
fraction of modification sites have been mapped. We developed a" filter aided sample …
Chemical glycoproteomics
Chemical tools have accelerated progress in glycoscience, reducing experimental barriers
to studying protein glycosylation, the most widespread and complex form of posttranslational …
to studying protein glycosylation, the most widespread and complex form of posttranslational …
[HTML][HTML] Proteomics: challenges, techniques and possibilities to overcome biological sample complexity
K Chandramouli, PY Qian - Human genomics and proteomics: HGP, 2009 - ncbi.nlm.nih.gov
Proteomics is the large-scale study of the structure and function of proteins in complex
biological sample. Such an approach has the potential value to understand the complex …
biological sample. Such an approach has the potential value to understand the complex …