The role of myeloperoxidase in biomolecule modification, chronic inflammation, and disease
Significance: The release of myeloperoxidase (MPO) by activated leukocytes is critical in
innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …
innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …
[HTML][HTML] Role of myeloperoxidase and oxidant formation in the extracellular environment in inflammation-induced tissue damage
The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …
Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease
BS Van der Veen, MPJ de Winther… - Antioxidants & redox …, 2009 - liebertpub.com
Abstract 2900 Myeloperoxidase (MPO) is a heme-containing peroxidase abundantly
expressed in neutrophils and to a lesser extent in monocytes. Enzymatically active MPO …
expressed in neutrophils and to a lesser extent in monocytes. Enzymatically active MPO …
Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential
Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …
Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention
MJ Davies - Journal of clinical biochemistry and nutrition, 2010 - jstage.jst.go.jp
抄録 There is considerable interest in the role that mammalian heme peroxidase enzymes,
primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide …
primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide …
Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease
B Chami, NJJ Martin, JM Dennis, PK Witting - Archives of biochemistry and …, 2018 - Elsevier
Inflammatory bowel disease (IBD) is a debilitating disorder involving inflammation of the
gastrointestinal tract. The incidence of IBD is increasing worldwide. Immunological …
gastrointestinal tract. The incidence of IBD is increasing worldwide. Immunological …
Myeloperoxidase: Mechanisms, reactions and inhibition as a therapeutic strategy in inflammatory diseases
MJ Davies - Pharmacology & Therapeutics, 2021 - Elsevier
Heme peroxidases are a major source of reactive oxidants at sites of inflammation in
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …
Myeloperoxidase: A versatile mediator of endothelial dysfunction and therapeutic target during cardiovascular disease
Myeloperoxidase (MPO) is a prominent mammalian heme peroxidase and a fundamental
component of the innate immune response against microbial pathogens. In recent times …
component of the innate immune response against microbial pathogens. In recent times …
Measuring chlorine bleach in biology and medicine
AJ Kettle, AM Albrett, AL Chapman, N Dickerhof… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Chlorine bleach, or hypochlorous acid, is the most reactive two-electron oxidant
produced in appreciable amounts in our bodies. Neutrophils are the main source of …
produced in appreciable amounts in our bodies. Neutrophils are the main source of …
Myeloperoxidase inhibitors as potential drugs
Myeloperoxidase (MPO) is an important member of the haem peroxidase-cyclooxygenase
superfamily. This enzyme is physiologically expressed in circulating neutrophils, monocytes …
superfamily. This enzyme is physiologically expressed in circulating neutrophils, monocytes …