Significance: The release of myeloperoxidase (MPO) by activated leukocytes is critical in
innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …

The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

Inflammatory bowel disease (IBD) is a debilitating disorder involving inflammation of the
gastrointestinal tract. The incidence of IBD is increasing worldwide. Immunological …

抄録 There is considerable interest in the role that mammalian heme peroxidase enzymes,
primarily myeloperoxidase, eosinophil peroxidase and lactoperoxidase, may play in a wide …

Abstract 2900 Myeloperoxidase (MPO) is a heme-containing peroxidase abundantly
expressed in neutrophils and to a lesser extent in monocytes. Enzymatically active MPO …

Oxidative stress has become widely viewed as an underlying condition in a number of
diseases, such as ischemia–reperfusion disorders, central nervous system disorders …

Rheumatoid arthritis (RA), a common chronic inflammatory illness, is still incurable, reducing
the sufferers' quality of life significantly. Adenosine 5′-triphosphate (ATP) and …

Heme peroxidases are a major source of reactive oxidants at sites of inflammation in
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …

Background Chlorine bleach, or hypochlorous acid, is the most reactive two-electron oxidant
produced in appreciable amounts in our bodies. Neutrophils are the main source of …

Parkinson's disease (PD) is a progressive neurodegenerative disorder that arises due to a
complex and variable interplay between elements including age, genetic, and …