High-throughput determination of RNA structures
RNA performs and regulates a diverse range of cellular processes, with new functional roles
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …
being uncovered at a rapid pace. Interest is growing in how these functions are linked to …
Advances in RNA 3D structure modeling using experimental data
RNA is a unique bio-macromolecule that can both record genetic information and perform
biological functions in a variety of molecular processes, including transcription, splicing …
biological functions in a variety of molecular processes, including transcription, splicing …
[HTML][HTML] The fragile X mental retardation protein binds specifically to its mRNA via a purine quartet motif
Fragile X syndrome is caused by the absence of protein FMRP, the function of which is still
poorly understood. Previous studies have suggested that FMRP may be involved in various …
poorly understood. Previous studies have suggested that FMRP may be involved in various …
DMS footprinting of structured RNAs and RNA–protein complexes
P Tijerina, S Mohr, R Russell - Nature protocols, 2007 - nature.com
We describe a protocol in which dimethyl sulfate (DMS) modification of the base-pairing
faces of unpaired adenosine and cytidine nucleotides is used for structural analysis of RNAs …
faces of unpaired adenosine and cytidine nucleotides is used for structural analysis of RNAs …
Mod-seq: high-throughput sequencing for chemical probing of RNA structure
The functions of RNA molecules are intimately linked to their ability to fold into complex
secondary and tertiary structures. Thus, understanding how these molecules fold is essential …
secondary and tertiary structures. Thus, understanding how these molecules fold is essential …
A novel function for fragile X mental retardation protein in translational activation
Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the
absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved …
absence of Fragile X Mental Retardation Protein (FMRP), an RNA-binding protein involved …
A single internal ribosome entry site containing a G quartet RNA structure drives fibroblast growth factor 2 gene expression at four alternative translation initiation …
S Bonnal, C Schaeffer, L Créancier, S Clamens… - Journal of Biological …, 2003 - ASBMB
The 484-nucleotide (nt) alternatively translated region (ATR) of the human fibroblast growth
factor 2 (FGF-2) mRNA contains four CUG and one AUG translation initiation codons …
factor 2 (FGF-2) mRNA contains four CUG and one AUG translation initiation codons …
Binding and cleavage of CRISPR RNA by Cas6
The CRISPR–Cas system provides many prokaryotes with acquired resistance to viruses
and other mobile genetic elements. The core components of this defense system are small …
and other mobile genetic elements. The core components of this defense system are small …
Native top-down mass spectrometry uncovers two distinct binding motifs of a functional neomycin-sensing riboswitch aptamer
SV Heel, K Bartosik, F Juen, C Kreutz… - Journal of the …, 2023 - ACS Publications
Understanding how ligands bind to ribonucleic acids (RNA) is important for understanding
RNA recognition in biological processes and drug development. Here, we have studied …
RNA recognition in biological processes and drug development. Here, we have studied …
Glyoxals as in vivo RNA structural probes of guanine base-pairing
D Mitchell, LE Ritchey, H Park, P Babitzke… - Rna, 2018 - rnajournal.cshlp.org
Elucidation of the folded structures that RNA forms in vivo is vital to understanding its
functions. Chemical reagents that modify the Watson–Crick (WC) face of unprotected …
functions. Chemical reagents that modify the Watson–Crick (WC) face of unprotected …