The conne**on between sex and immune responses

KS Forsyth, N Jiwrajka, CD Lovell… - Nature Reviews …, 2024‏ - nature.com
There are notable sex-based differences in immune responses to pathogens and self-
antigens, with female individuals exhibiting increased susceptibility to various autoimmune …

Streptozotocin as a tool for induction of rat models of diabetes: A practical guide

A Ghasemi, S Jeddi - EXCLI journal, 2023‏ - pmc.ncbi.nlm.nih.gov
Streptozotocin (STZ) is the most used diabetogenic chemical for creating rat models of type
1 and type 2 diabetes. Despite~ 60 years of using STZ in animal diabetes research, some …

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

N Percie du Sert, V Hurst, A Ahluwalia… - Journal of Cerebral …, 2020‏ - journals.sagepub.com
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

[HTML][HTML] Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

NP Du Sert, A Ahluwalia, S Alam, MT Avey… - PLoS …, 2020‏ - journals.plos.org
Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

A systematic review of automatic question generation for educational purposes

G Kurdi, J Leo, B Parsia, U Sattler… - International Journal of …, 2020‏ - Springer
While exam-style questions are a fundamental educational tool serving a variety of
purposes, manual construction of questions is a complex process that requires training …

The laboratory rat: Age and body weight matter

A Ghasemi, S Jeddi, K Kashfi - EXCLI journal, 2021‏ - pmc.ncbi.nlm.nih.gov
Animal experimentation helps us to understand human biology. Rodents and, in particular,
rats are among the most common animals used in animal experiments. Reporting data on …

[HTML][HTML] Inclusion of females does not increase variability in rodent research studies

AK Beery - Current opinion in behavioral sciences, 2018‏ - Elsevier
Highlights•Female subjects are underrepresented in animal research.•Recent studies
demonstrate that unstaged female rodents are no more variable than males.•Factorial …

Bridging bio–nano science and cancer nanomedicine

M Bjornmalm, KJ Thurecht, M Michael, AM Scott… - ACS …, 2017‏ - ACS Publications
The interface of bio–nano science and cancer medicine is an area experiencing much
progress but also beset with controversy. Core concepts of the field eg, the enhanced …

Female rats are not more variable than male rats: a meta-analysis of neuroscience studies

JB Becker, BJ Prendergast, JW Liang - Biology of sex differences, 2016‏ - Springer
Background Not including female rats or mice in neuroscience research has been justified
due to the variable nature of female data caused by hormonal fluctuations associated with …

Considering sex as a biological variable will be valuable for neuroscience research

RM Shansky, CS Woolley - Journal of Neuroscience, 2016‏ - jneurosci.org
The recently implemented National Institutes of Health policy requiring that grant applicants
consider sex as a biological variable in the design of basic and preclinical animal research …