Privileged scaffolds as starting points toward biologically active molecules represent a
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …

Dopamine is a biologically active amine synthesized in the central and peripheral nervous
system. This biogenic monoamine acts by activating five types of dopamine receptors (D1 …

A series of novel aminopyrimidinyl benzimidazoles as potentially antimicrobial agents were
designed, synthesized and characterized by IR, NMR and HRMS spectra. The biological …

A dual-tail approach was applied to the design of a novel series of 2-thiopyrimidine–
benzenesulfonamides as carbonic anhydrase (CA) inhibitors. The design strategy is based …

Malaria is a protozoan disease caused by a unicellular parasite named Plasmodium
(Phylum-Apicomplexa). World Health Organization has estimated roughly fifty percent of the …

Scaffolds hybridization is a well-known drug design strategy for antitumor agents. Herein,
series of novel indolyl-pyrimidine hybrids were synthesized and evaluated in vitro and in …

This work explored a novel type of potential multi-targeting antimicrobial three-component
sulfanilamide hybrids in combination of pyrimidine and azoles. The hybridized target …

The PTPN11 oncogene encodes the cytoplasmic protein tyrosine phosphatase SHP2,
which, through its role in multiple signaling pathways, promotes the progression of …

The new single crystal, bis (2-chloro-4, 6-diaminopyrimidine)-copper (II)-dichloride [CDPCD]
compound was synthesized. The crystal structure of the compound was solved by the single …

Two new series of 2‐thiocyclopenta [d] pyrimidine‐benzenesulfonamides 12a–l and 2‐
thiotetrahydroquinazoline‐benzenesulfonamides 13a–j were synthesized and evaluated for …