HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment

D Saylor, AM Dickens, N Sacktor, N Haughey… - Nature Reviews …, 2016 - nature.com
In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …

HIV, depression, and cognitive impairment in the era of effective antiretroviral therapy

LH Rubin, PM Maki - Current HIV/aids Reports, 2019 - Springer
Abstract Purpose of Review Mental health disorders, especially depression, are prevalent
among people living with HIV (PLWH) and are associated with cognitive impairment (CI) …

Prevalence of HIV-associated neurocognitive disorders in the Multicenter AIDS Cohort Study

N Sacktor, RL Skolasky, E Seaberg, C Munro… - Neurology, 2016 - neurology.org
Objective: To evaluate the frequency of HIV-associated neurocognitive disorder (HAND) in
HIV+ individuals and determine whether the frequency of HAND changed over 4 years of …

Cognitive disorders in people living with HIV

A Winston, S Spudich - The Lancet HIV, 2020 - thelancet.com
High rates of cognitive disorders in antiretroviral-treated people living with HIV have been
described worldwide. The exact prevalence of such cognitive disorders is determined by the …

Twelve-year neurocognitive decline in HIV is associated with comorbidities, not age: a CHARTER study

RK Heaton, RJ Ellis, B Tang, CM Marra, LH Rubin… - Brain, 2023 - academic.oup.com
Modern antiretroviral therapy (ART) has increased longevity of people with HIV and shifted
the age distribution of the HIV pandemic upward toward that of the general population. This …

[HTML][HTML] HIV and aging

EJ Wing - International journal of infectious diseases, 2016 - Elsevier
With the wider availability of antiretrovirals, the world's HIV population is aging. More than
10% of the 34.5 million HIV-positive individuals worldwide are over the age of 50 years and …

The kynurenine pathway relates to post‐acute COVID‐19 objective cognitive impairment and PASC

LA Cysique, D Jakabek, SG Bracken… - Annals of Clinical …, 2023 - Wiley Online Library
Objective To determine the prevalence and natural history of post‐acute COVID‐19
objective cognitive impairment and function, and their relationship to demographic, clinical …

Gut microbiota and cognitive performance: A bidirectional two-sample Mendelian randomization

Q Wang, Y Song, X Wu, Y Luo, R Miao, X Yu… - Journal of Affective …, 2024 - Elsevier
Purpose Previous studies have suggested a potential association between gut microbiota
and neurological and psychiatric disorders. However, the causal relationship between gut …

Advances toward curing HIV-1 infection in tissue reservoirs

LJ Henderson, LB Reoma, JA Kovacs, A Nath - Journal of virology, 2020 - journals.asm.org
ABSTRACT A disease of more than 39.6 million people worldwide, HIV-1 infection has no
curative therapy. To date, one man has achieved a sterile cure, with millions more ho** to …

Mechanisms of CNS Viral Seeding by HIV+ CD14+ CD16+ Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated …

M Veenstra, R León-Rivera, M Li, L Gama… - MBio, 2017 - journals.asm.org
ABSTRACT HIV reservoirs persist despite antiretroviral therapy (ART) and are established
within a few days after infection. Infected myeloid cells in the central nervous system (CNS) …