Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …

Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

Metastasis is not the result of a random event, as cancer cells can sustain and proliferate
actively only in a suitable tissue microenvironment and then form metastases. Since Dr …

Tumour hypoxia is increasingly recognized as a major deleterious factor in cancer therapies,
as it compromises treatment and drives malignant progression. This review seeks to clarify …

A compelling body of evidence indicates that most human solid tumors contain hypoxic
areas. Hypoxia is the consequence not only of the chaotic proliferation of cancer cells that …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

Portal vein tumor thrombosis (PVTT) is a significant risk factor for metastasis in
hepatocellular carcinoma (HCC) patients and is therefore associated with poor prognosis …

Hypoxia is known to be a poor prognostic indicator for nearly all solid tumours and also is
predictive of treatment failure for radiotherapy, chemotherapy, surgery and targeted …

Human solid tumors are invariably less well‐oxygenated than the normal tissues from which
they arose. This so‐called tumor hypoxia leads to resistance to radiotherapy and anticancer …

Simple Summary The term hypoxia is used to describe biological situations where
insufficient levels of oxygen exist. Hypoxia and hypoxic states can occur in a range of …