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Current development of 1, 2, 3-triazole derived potential antimalarial scaffolds: Structure-activity relationship (SAR) and bioactive compounds
Malaria is among one of the most devastating and deadliest parasitic disease in the world
claiming millions of lives every year around the globe. It is a mosquito-borne infectious …
claiming millions of lives every year around the globe. It is a mosquito-borne infectious …
Aqueous micelles as solvent, ligand, and reaction promoter in catalysis
Water is considered to be the most sustainable and safest solvent. Micellar catalysis is a
significant contributor to the chemistry in water. It promotes pathways involving water …
significant contributor to the chemistry in water. It promotes pathways involving water …
Azide-alkyne click chemistry over a heterogeneous copper-based single-atom catalyst
One-pot three-component regioselective azide-alkyne cycloadditions are central reactions
for synthesizing pharmaceuticals and fine chemicals and are also applied for in vivo …
for synthesizing pharmaceuticals and fine chemicals and are also applied for in vivo …
Glycopolymers for drug delivery: opportunities and challenges
MH Stenzel - Macromolecules, 2022 - ACS Publications
Glycopolymers are synthetic polymers with pendant sugars, which hold promise for a range
of biomedical applications ranging from tissue engineering to sensing. The known specific …
of biomedical applications ranging from tissue engineering to sensing. The known specific …
Synthesis, molecular features and biological activities of modified plant polysaccharides
S Mukherjee, S Jana, S Khawas, J Kicuntod… - Carbohydrate …, 2022 - Elsevier
Plant polysaccharides represent a natural source material characterized by high ubiquity,
abundance and biological activities that can be utilised as organic matter in numerous …
abundance and biological activities that can be utilised as organic matter in numerous …
The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
chemistry due to its unique structural properties, synthetic versatility and pharmacological …
Enzyme-mediated bioorthogonal cascade catalytic reaction for metabolism intervention and enhanced ferroptosis on neuroblastoma
Q Wang, X Li, Z Cao, W Feng, Y Chen… - Journal of the American …, 2024 - ACS Publications
It remains a tremendous challenge to explore effective therapeutic modalities against
neuroblastoma, a lethal cancer of the sympathetic nervous system with poor prognosis and …
neuroblastoma, a lethal cancer of the sympathetic nervous system with poor prognosis and …
[HTML][HTML] Click chemistry and drug delivery: A bird's-eye view
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …
a large number of click reactions with a various characteristics, selection of appropriate …
A Polyoxometalate‐Based Pathologically Activated Assay for Efficient Bioorthogonal Catalytic Selective Therapy
H Zhao, C Zhao, Z Liu, J Yi, X Liu… - Angewandte Chemie …, 2023 - Wiley Online Library
Since polyoxometalates (POMs) can undergo reversible multi‐electron redox
transformations, they have been used to modulate the electronic environment of metal …
transformations, they have been used to modulate the electronic environment of metal …
Chemical synthesis of modified RNA
L Flemmich, R Bereiter, R Micura - Angewandte Chemie, 2024 - Wiley Online Library
Ribonucleic acids (RNAs) play a vital role in living organisms. Many of their cellular
functions depend critically on chemical modification. Methods to modify RNA in a controlled …
functions depend critically on chemical modification. Methods to modify RNA in a controlled …