Current development of 1, 2, 3-triazole derived potential antimalarial scaffolds: Structure-activity relationship (SAR) and bioactive compounds

SMA Rahman, JS Bhatti, S Thareja, V Monga - European Journal of …, 2023 - Elsevier
Malaria is among one of the most devastating and deadliest parasitic disease in the world
claiming millions of lives every year around the globe. It is a mosquito-borne infectious …

Aqueous micelles as solvent, ligand, and reaction promoter in catalysis

JK Virdi, A Dusunge, S Handa - JACS Au, 2024 - ACS Publications
Water is considered to be the most sustainable and safest solvent. Micellar catalysis is a
significant contributor to the chemistry in water. It promotes pathways involving water …

Azide-alkyne click chemistry over a heterogeneous copper-based single-atom catalyst

G Vilé, G Di Liberto, S Tosoni, A Sivo, V Ruta… - ACS …, 2022 - ACS Publications
One-pot three-component regioselective azide-alkyne cycloadditions are central reactions
for synthesizing pharmaceuticals and fine chemicals and are also applied for in vivo …

Glycopolymers for drug delivery: opportunities and challenges

MH Stenzel - Macromolecules, 2022 - ACS Publications
Glycopolymers are synthetic polymers with pendant sugars, which hold promise for a range
of biomedical applications ranging from tissue engineering to sensing. The known specific …

Synthesis, molecular features and biological activities of modified plant polysaccharides

S Mukherjee, S Jana, S Khawas, J Kicuntod… - Carbohydrate …, 2022 - Elsevier
Plant polysaccharides represent a natural source material characterized by high ubiquity,
abundance and biological activities that can be utilised as organic matter in numerous …

The 1, 2, 3-triazole 'all-in-one'ring system in drug discovery: A good bioisostere, a good pharmacophore, a good linker, and a versatile synthetic tool

D Lengerli, K Ibis, Y Nural… - Expert opinion on drug …, 2022 - Taylor & Francis
ABSTRACT Introduction The 1, 2, 3-triazole ring occupies an important space in medicinal
chemistry due to its unique structural properties, synthetic versatility and pharmacological …

Enzyme-mediated bioorthogonal cascade catalytic reaction for metabolism intervention and enhanced ferroptosis on neuroblastoma

Q Wang, X Li, Z Cao, W Feng, Y Chen… - Journal of the American …, 2024 - ACS Publications
It remains a tremendous challenge to explore effective therapeutic modalities against
neuroblastoma, a lethal cancer of the sympathetic nervous system with poor prognosis and …

[HTML][HTML] Click chemistry and drug delivery: A bird's-eye view

SM Kondengadan, S Bansal, C Yang, D Liu… - … Pharmaceutica Sinica B, 2023 - Elsevier
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …

A Polyoxometalate‐Based Pathologically Activated Assay for Efficient Bioorthogonal Catalytic Selective Therapy

H Zhao, C Zhao, Z Liu, J Yi, X Liu… - Angewandte Chemie …, 2023 - Wiley Online Library
Since polyoxometalates (POMs) can undergo reversible multi‐electron redox
transformations, they have been used to modulate the electronic environment of metal …

Chemical synthesis of modified RNA

L Flemmich, R Bereiter, R Micura - Angewandte Chemie, 2024 - Wiley Online Library
Ribonucleic acids (RNAs) play a vital role in living organisms. Many of their cellular
functions depend critically on chemical modification. Methods to modify RNA in a controlled …