Unsupervised learning methods for molecular simulation data

A Glielmo, BE Husic, A Rodriguez, C Clementi… - Chemical …, 2021 - ACS Publications
Unsupervised learning is becoming an essential tool to analyze the increasingly large
amounts of data produced by atomistic and molecular simulations, in material science, solid …

CellRank for directed single-cell fate map**

M Lange, V Bergen, M Klein, M Setty, B Reuter… - Nature …, 2022 - nature.com
Computational trajectory inference enables the reconstruction of cell state dynamics from
single-cell RNA sequencing experiments. However, trajectory inference requires that the …

Toroidal topology of population activity in grid cells

RJ Gardner, E Hermansen, M Pachitariu, Y Burak… - Nature, 2022 - nature.com
The medial entorhinal cortex is part of a neural system for map** the position of an
individual within a physical environment. Grid cells, a key component of this system, fire in a …

Understanding how dimension reduction tools work: an empirical approach to deciphering t-SNE, UMAP, TriMAP, and PaCMAP for data visualization

Y Wang, H Huang, C Rudin, Y Shaposhnik - Journal of Machine Learning …, 2021 - jmlr.org
Dimension reduction (DR) techniques such as t-SNE, UMAP, and TriMap have
demonstrated impressive visualization performance on many real-world datasets. One …

Tutorial: guidelines for the computational analysis of single-cell RNA sequencing data

TS Andrews, VY Kiselev, D McCarthy, M Hemberg - Nature protocols, 2021 - nature.com
Single-cell RNA sequencing (scRNA-seq) is a popular and powerful technology that allows
you to profile the whole transcriptome of a large number of individual cells. However, the …

Umap: Uniform manifold approximation and projection for dimension reduction

L McInnes, J Healy, J Melville - arxiv preprint arxiv:1802.03426, 2018 - arxiv.org
UMAP (Uniform Manifold Approximation and Projection) is a novel manifold learning
technique for dimension reduction. UMAP is constructed from a theoretical framework based …

Tutorial: guidelines for annotating single-cell transcriptomic maps using automated and manual methods

ZA Clarke, TS Andrews, J Atif, D Pouyabahar… - Nature protocols, 2021 - nature.com
Single-cell transcriptomics can profile thousands of cells in a single experiment and identify
novel cell types, states and dynamics in a wide variety of tissues and organisms. Standard …

Single-cell transcriptome analysis in plants: advances and challenges

R Shaw, X Tian, J Xu - Molecular Plant, 2021 - cell.com
The rapid and enthusiastic adoption of single-cell RNA sequencing (scRNA-seq) has
demonstrated that this technology is far more than just another way to perform transcriptome …